Engineers have modified lipid nanoparticles (LNPs) -- the revolutionary technology behind the COVID-19 mRNA vaccines -- to not only cross the blood-brain barrier (BBB) but also to target specific types of cells, including neurons. This breakthrough marks a significant step toward potential next-generation treatments for neurological diseases like Alzheimer's and Parkinson's.
Read more …Peptide-guided nanoparticles deliver mRNA to neurons
By taking advantage of a 'giving up' behavior exhibited by zebrafish, the ability to image the fish's entire brain, and a unique virtual reality system, a team of researchers found where ketamine acts in the zebrafish brain: at supporting cells called astroglia, rather than neurons.
Read more …Discouraged zebrafish help reveal how ketamine works in the brain