Glioblastoma is the most common kind of malignant brain tumor in adults. So far, no treatment has been able to make this aggressive tumor permanently disappear. The tumor cells are too varied, and the microenvironment is too tumor-friendly. Researchers have now developed an immunotherapy that not only attacks the tumor -- it also turns its microenvironment against it.
Read more …Glioblastoma: New treatment attacks brain tumors from multiple angles
Researchers reveal that metabolic enzymes known for their roles in energy production and nucleotide synthesis are taking on unexpected 'second jobs' within the nucleus, orchestrating critical functions like cell division and DNA repair. The discovery not only challenges longstanding biological paradigms in cellular biology but also opens new avenues for cancer therapies, particularly against aggressive tumours like triple-negative breast cancer (TNBC).
Read more …'Moonlighting' enzymes can lead to new cancer therapies