Metabolic dysfunction-associated steatotic liver disease is currently the most widespread liver disorder globally, affecting roughly one in three adults. It occurs when excess fat builds up inside liver cells, leading to serious liver damage and a higher risk of death from cardiovascular disease.

Researchers at the University of Barcelona have now found a promising approach that could change how this condition is treated. Their study, published in Pharmacological Research, reports that two existing drugs, pemafibrate and telmisartan, significantly reduced fat buildup in animal models of metabolic liver disease. The findings also suggest that using these medications together could ease liver damage while lowering related heart and blood vessel complications. Because available treatments for this disease remain very limited, the results point to a potentially safer and more effective therapeutic option.

The research was led by Marta Alegret, a professor at the University of Barcelona's Faculty of Pharmacy and Food Sciences, and a member of the Institute of Biomedicine of the UB (IBUB) and the CIBER Area for Physiopathology of Obesity and Nutrition (CIBEROBN). The work was conducted in collaboration with scientists from the Santa Creu i Sant Pau Hospital Research Institute, the Hospital Clínic de Barcelona, the CIBER Area for Cardiovascular Diseases (CIBERCV), and Uppsala University (Sweden).

​​​​​​​Drug repurposing, a promising and cost-effective strategy

To date, most new experimental compounds developed for metabolic dysfunction-associated steatotic liver disease (MASLD) -- formerly known as fatty liver disease -- have failed during clinical trials, often because of safety concerns. This has turned attention toward drug repurposing, a strategy that explores new uses for medications already proven to be safe in humans. Such an approach is not only faster and more affordable but also particularly valuable for treating the early, often symptom-free stages of MASLD.

"We have focused on these phases with the aim of preventing the disease from progressing to more severe stages. But for a drug to be used in these early stages, it must have a good safety profile in humans," explains Marta Alegret. "That is why we have studied drugs already on the market for other pathologies, which have been shown to be very safe and could have a potential benefit in the treatment of MASLD," she adds.

In this study, the team evaluated the potential of two approved medications, given separately and together: a lipid-lowering agent (pemafibrate) and an antihypertensive drug (telmisartan). The first is marketed only in Japan, while the second is widely used for high blood pressure. Both are prescribed to reduce cardiovascular risk. "Mortality from cardiovascular causes is significant in patients with MASLD, and often these patients also have these two risk factors together," Alegret stresses.

Zebrafish larvae, an alternative model for studying the disease

To confirm the efficacy of the drugs and explore their mechanism of action, the researchers have applied them to a rat model of the disease and, subsequently, to a zebrafish larval model. "In recent years, zebrafish have emerged as an interesting alternative model that facilitates the study of the pathophysiology of MASLD and the evaluation of treatments. These are simpler and cheaper models that allow results to be obtained more quickly and which, although they are not identical to humans, have a carbohydrate/lipid metabolism and liver physiology similar to those of mammals," says the UB professor.

The results show that the combination of the two drugs reverses the fat accumulation in the liver induced by a diet high in fat and fructose. In addition, in the rat model, the combined administration of half a dose of pemafibrate and half a dose of telmisartan was found to be as effective as a full dose of either drug in reducing fat accumulation. "Combination therapy with drugs acting on different pathogenic pathways may be a better strategy than monotherapy, thanks to possible synergistic effects and reduced toxicity related to the use of lower doses of each drug," Alegret points out.

The combination of these two drugs would be beneficial not only for liver disease, but also because "it lowers blood pressure and cholesterol levels, and all this would result in a lower cardiovascular risk," she stresses.

​​​​​​​Different lipid-lowering mechanisms The study also found that each drug works by different mechanisms and describes, for the first time, the key role of the PCK1 protein in telmisartan-derived hepatic lipid lowering. "Telmisartan is a drug that has been used in other models of MASLD, but mostly in more advanced stages of the disease, and its beneficial effects have been attributed mainly to anti-inflammatory and anti-fibrotic effects. But in the early stages of the disease there is no inflammation or fibrosis yet, only lipid accumulation," explains the researcher.

Researchers have now found that the amount of PCK1 protein in the livers of MASLD animals was reduced and that treatment with telmisartan restored its levels to normal. "This increase in PCK1 diverts the flux of metabolites from lipid synthesis to glucose synthesis. This increase in glucose production could be negative if the glucose were exported and accumulated in the blood, as it could lead to diabetes, but we have noticed that this is not the case," says the UB professor.

Still far from clinical application

Despite these promising results, the researchers point out that, as this is a study using animal models, they are still far from patients. "In order to be translated into a treatment for MASLD patients, clinical studies would be needed to show that the benefits observed in animal models also occur in humans," says Alegret. ​​​​​​​ In any case, the results raise new questions, such as whether the drugs will be equally effective in more advanced stages of the disease, when fibrosis is present. The research team is therefore already working on new studies in animal models of diet-induced liver fibrosis. "In addition, we will develop a dual model involving liver fibrosis and cardiovascular disease to see if the beneficial action is observed not only in the liver, but also in the reduction of atherosclerosis," he concludes.

Read more …Two common drugs could reverse fatty liver disease

Date:
Source:
American Chemical Society
Summary:
Researchers are finding extraordinary new uses for what we throw away. Beet pulp may help crops resist disease, while composted coconut fibers could replace peat moss. Discarded radish and beet greens are rich in bioactive compounds that boost gut health and protect cells. Food waste is rapidly becoming a source of sustainable solutions for both agriculture and health.

FULL STORY


Scientists Find Gold Hiding in Food Waste
Trash is turning into treasure as food waste fuels breakthroughs in farming, health, and sustainability. Credit: Shutterstock

Food waste can be far more valuable than the pile of scraps left behind after a meal. Scientists are uncovering surprising ways to turn discarded materials -- from dried beet pulp to coconut fibers processed by millipedes -- into useful resources. In four new studies published in ACS journals, researchers reveal how food waste can offer eco-friendly tools for agriculture and new sources of beneficial compounds for medicine.

1. Sugar by-product may "beet" wheat disease.

In a study published in ACS' Journal of Agricultural and Food Chemistry, researchers found that sugar beet pulp could help farmers cut down on synthetic pesticide use. This leftover pulp, which makes up about 80% of the beet after sugar extraction, was transformed into carbohydrates that trigger plants' natural immune responses. When tested on wheat, these compounds helped protect against fungal infections such as powdery mildew.

2. Composted coconuts help seedlings grow.

Coconut fibers broken down by millipedes may serve as a sustainable replacement for peat moss, a material commonly used to start seedlings but often sourced from fragile wetland ecosystems. A study published in ACS Omega explored this "millicompost" and found that, when combined with other plant materials, it supported the healthy growth of bell pepper seedlings as effectively as traditional peat-based mixes.

3. Radish leaves support gut health.

A review in ACS' Journal of Agricultural and Food Chemistry suggests that the often-discarded tops of radishes could be more nutritious than the roots themselves. These peppery greens contain abundant fiber and bioactive compounds, including polysaccharides and antioxidants. In lab and animal studies, they promoted the growth of beneficial gut microbes, hinting that they might also boost digestive health in humans.

4. Beet greens supply bioactive ingredients.

Research described in ACS Engineering Au outlines a way to preserve the powerful compounds extracted from beet leaves for use in food, cosmetics, and pharmaceuticals. Scientists created microparticles by drying a mixture of antioxidant-rich beet-green extract with an edible biopolymer. The resulting encapsulated particles not only remained stable but also showed greater antioxidant activity than the uncoated extract, suggesting that this process helps protect the bioactive ingredients from degradation.


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Materials provided by American Chemical Society. Note: Content may be edited for style and length.


Journal References:

  1. Camille Carton, Josip Šafran, Sangeetha Mohanaraj, Romain Roulard, Jean-Marc Domon, Solène Bassard, Natacha Facon, Benoît Tisserant, Gaelle Mongelard, Laurent Gutierrez, Béatrice Randoux, Maryline Magnin-Robert, Jérôme Pelloux, Corinne Pau-Roblot, Anissa Lounès-Hadj Sahraoui. Valorization of Sugar Beet Byproducts into Oligogalacturonides with Protective Activity against Wheat Powdery Mildew. Journal of Agricultural and Food Chemistry, 2025; 73 (38): 24237 DOI: 10.1021/acs.jafc.5c05099[1]
  2. Luiz Fernando de Sousa Antunes, André Felipe de Sousa Vaz, Giulia da Costa Rodrigues dos Santos, Talita dos Santos Ferreira, Renata Rodrigues dos Santos, Renata dos Santos Alves, Jaqueline Carvalho de Almeida, Marco Antonio de Almeida Leal, Maria Elizabeth Fernandes Correia. Replacing Commercial Substrate with Millicompost: A Sustainable Approach Using Different Green Wastes Combined with Millicompost for Bell Pepper Seedling Production in Urban Agriculture. ACS Omega, 2025; 10 (37): 43129 DOI: 10.1021/acsomega.5c06388[2]
  3. Wonchan Yoon, Miri Park, Guijae Yoo, Young-Soo Kim, Ho-Young Park. Bioactive Compounds and Health Benefits of Radish Greens. Journal of Agricultural and Food Chemistry, 2025; 73 (39): 24517 DOI: 10.1021/acs.jafc.5c08263[3]
  4. Leonardo de Freitas Marinho, Stefania Mottola, Henrique Di Domenico Ziero, Larissa Castro Ampese, Mariarosa Scognamiglio, Iolanda De Marco, Ernesto Reverchon, Tânia Forster Carneiro. Evaluation of Microparticles Obtained from Beet Leaf Extracts (Beta vulgaris L.) Using Supercritical Assisted Atomization (SAA). ACS Engineering Au, 2025; DOI: 10.1021/acsengineeringau.5c00044[4]

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American Chemical Society. "Scientists find gold hiding in food waste." ScienceDaily. ScienceDaily, 12 October 2025. <www.sciencedaily.com/releases/2025/10/251011105518.htm>.

American Chemical Society. (2025, October 12). Scientists find gold hiding in food waste. ScienceDaily. Retrieved October 12, 2025 from www.sciencedaily.com/releases/2025/10/251011105518.htm

American Chemical Society. "Scientists find gold hiding in food waste." ScienceDaily. www.sciencedaily.com/releases/2025/10/251011105518.htm (accessed October 12, 2025).

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Read more …Scientists find gold hiding in food waste

How Older Adults Regain Happiness
Nearly one-quarter of older adults regained top well-being within three years, even after struggling. Emotional health, physical activity, and good sleep were strong predictors of recovery. Credit: Shutterstock

Almost one in four adults aged 60 and older who initially reported poor well-being managed to regain a state of optimal well-being within three years, according to research published on September 24, 2025, in PLOS One by Mabel Ho and Esme Fuller-Thomson of the University of Toronto, Canada. The findings emphasize the importance of maintaining a healthy lifestyle through actions such as keeping a stable body weight, avoiding smoking, staying physically active, improving sleep, and preventing or managing chronic illnesses. The study also underscores the role of psychological, emotional, and social wellness in overall quality of life.

Interest in understanding what drives resilience and long-term well-being is growing. Many lifestyle choices can influence the ability to maintain good health and happiness, defined in this research as a combination of physical, psychological, emotional, social, and self-rated well-being, even in the presence of chronic conditions. However, only a small number of studies have focused on what helps people recover or regain a strong sense of well-being later in life after experiencing difficulty.

Using data from the Canadian Longitudinal Study on Aging, Ho and Fuller-Thomson analyzed 8,332 adults who did not initially meet the criteria for optimal well-being and followed up with them three years later, when all participants were at least 60 years old.

They discovered that nearly one-quarter of these participants had achieved optimal well-being by the end of that period. Those who already showed signs of psychological and emotional wellness at the beginning were nearly five times more likely to recover full well-being than those who did not.

The likelihood of regaining well-being was also higher among participants who were younger (under 70 years old), married, and earning incomes above the poverty line. Better outcomes were linked to being physically active, not smoking, sleeping well, and avoiding chronic conditions such as obesity, diabetes, arthritis, or osteoporosis.

Because all Canadian citizens and permanent residents have access to publicly funded healthcare, the researchers note that these results may not apply to countries where medical care depends on the ability to pay. They also caution that the findings may not extend to low- and middle-income nations.

If future research establishes that the associations observed in the current study are causal, policies and interventions that support physical, psychological, emotional, social, and self-rated wellness might help older adults to regain optimal well-being. For example, programs and services can be provided to encourage older adults to engage in an active and healthy lifestyle, to manage chronic conditions, and to prevent social isolation. According to the authors, these interventions might play an important role in enhancing older adults' resilience and enabling them to regain optimal well-being in later life.

"What's powerful about this research is the reminder that later life can still be fulfilling, even after difficult periods. Good health is important, but so are the people, meaning, and joy we have in our lives," says first author Mabel Ho, a recent doctoral graduate at the University of Toronto's Factor-Inwentash Faculty of Social Work (FIFSW) and the Institute of Life Course and Aging.

"This is a clear call to invest in prevention, financial stability, and accessible wellness supports -- because these aren't just smart policies, they can potentially improve the trajectory of aging for older adults who are struggling," says senior author Esme Fuller-Thomson, Director of the Institute for Life Course & Aging and Professor at the University of Toronto's Factor-Inwentash Faculty of Social Work.

Read more …How 1 in 4 older adults regain happiness after struggling

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