Fever temperatures rev up immune cell metabolism, proliferation and activity, but they also -- in a particular subset of T cells -- cause mitochondrial stress, DNA damage and cell death, researchers have discovered. The findings offer a mechanistic understanding for how cells respond to heat and could explain how chronic inflammation contributes to the development of cancer.
Read more …Fever drives enhanced activity, mitochondrial damage in immune cells
Researchers investigated differences in T-cell responses between male and female patients with lung cancer that may help direct future treatments. T-cell responses are part of the adaptive immune system, which is part of the body's 'smart system' that monitors for threats and fights them with customized defenses.
Read more …Researchers identify sex-based differences in immune responses against tumors
Investigators developed the largest collection of sarcoma patient-derived organoids to date that can help improve the understanding of the disease and better identify therapies that are most likely to work for each individual patient. By using 3D mini tumor models that closely resemble a patient's tumor, treatments could be tailored more effectively, paving the way for more personalized cancer treatments.
Read more …Unlocking the potential of patient-derived organoids for personalized sarcoma treatment