A 28-day trial showed that pterostilbene cream improved wrinkles, skin firmness, collagen, and pore size far better than a control emulsion. The results highlight pterostilbene as a promising natural ingredient for next-generation anti-aging skincare.
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Researchers testing a pterostilbene-based anti-aging cream found it greatly improved skin firmness, elasticity, and wrinkle reduction compared to a control. The results suggest this natural ingredient could become a game-changer in cosmetic formulations. Credit: Shutterstock
Against the backdrop of high market demand for effective anti-ageing cosmetics, a team of Chinese researchers assessed the clinical effectiveness of a 0.1 % pterostilbene-containing skincare emulsion against a control emulsion over 28 days with 31 participants.
The study employed a double-blind, split-face design, comparing the left and right sides of the face and using advanced instruments along with subject self-assessments. The set of instruments used, together with the findings, is reported in the team's published article in the Journal of Dermatologic Science and Cosmetic Technology.
"Our results indicated that the pterostilbene emulsion remarkably improved skin elasticity, firmness, and reduced wrinkles, such as forehead, undereye, and Crow's feet wrinkles, shares co-author Zhiyuan Chen, Founder of Guangzhou Luanying Cosmetics Co., Ltd. "It also increased the thickness of the epidermis layer, enhanced collagen and elastic fibers, and minimized skin pores."
Compared to the control emulsion, the pterostilbene emulsion brought about statistically significant improvements, and all subjects expressed higher satisfaction with the pterostilbene emulsion. These results collectively demonstrated the superior anti-aging efficacy of the pterostilbene emulsion through multiple mechanisms.
According to corresponding author Xueping Chen, the findings advance our understanding of pterostilbene's role in skincare by providing evidence of its potent anti-ageing effects and supporting its use as an active ingredient in cosmetics. "It also offers a new perspective on natural compounds' applications in the skincare industry," says Chen. "The significant improvements in various skin parameters and the subjects' positive feedback highlight the effectiveness of pterostilbene, which may change the way we approach anti-ageing skincare formulations."
The authors propose a longer study period to fully understand the impact of pterostilbene.
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Materials provided by KeAi Communications Co., Ltd.. Note: Content may be edited for style and length.
Journal Reference:
Zongxiao Cen, Zhiyuan Chen, Ding Wang, Yuqin Zuo, Junyuan Chen, Xueping Chen. Anti-aging Efficacy of a 0.1 % Pterostilbene Skincare Emulsion: A 28-Day Clinical Trial. Journal of Dermatologic Science and Cosmetic Technology, 2025; 2 (2): 100083 DOI: 10.1016/j.jdsct.2025.100083[1]
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KeAi Communications Co., Ltd.. "Scientists test an anti-aging cream that actually works." ScienceDaily. ScienceDaily, 15 September 2025. <www.sciencedaily.com/releases/2025/09/250914205851.htm>.
KeAi Communications Co., Ltd.. (2025, September 15). Scientists test an anti-aging cream that actually works. ScienceDaily. Retrieved September 15, 2025 from www.sciencedaily.com/releases/2025/09/250914205851.htm
KeAi Communications Co., Ltd.. "Scientists test an anti-aging cream that actually works." ScienceDaily. www.sciencedaily.com/releases/2025/09/250914205851.htm (accessed September 15, 2025).
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In the lobby of the YMCA in Reading[1], Pennsylvania, stands a row of vending machines – but one machine is different from the rest.
Instead of stocking chips or soda, this vending machine has drug-testing strips, hygiene kits, socks, soap, wound care supplies[2] and naloxone[3], a medication also known by its brand name Narcan that is used to reverse opioid overdoses – all completely free.
A sweeping global study reveals that nearly half of people with diabetes don’t even know they have it, with young adults being the most overlooked. While most diagnosed patients receive treatment, less than half achieve proper blood sugar control, leaving only about one in five with well-managed diabetes.
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Nearly half of diabetes cases remain undiagnosed, and even among those treated, only a fraction achieve proper control. Without stronger screening and better access to care, the world faces a fast-approaching diabetes crisis. Credit: Shutterstock
A large portion of the global population with diabetes remains undiagnosed or is not receiving optimal care, according to a new study published in The Lancet Diabetes & Endocrinology. The Institute for Health Metrics and Evaluation (IHME) at the University of Washington School of Medicine and a global network of collaborators conducted the analysis of the diabetes care cascade for all ages, both sexes, and 204 countries and territories from 2000 to 2023.
In 2023, an estimated 44% of people aged 15 and older with diabetes are unaware of their condition. Underdiagnosis was greatest among young adults -- despite facing higher risks for long-term complications.
Among those who were diagnosed, 91% were on some form of pharmacological treatment. However, of those receiving treatment, only 42% had their blood sugar levels managed optimally. This translates to just 21% of all people with diabetes globally having their condition under optimal management.
Despite improvements over two decades, the research also found substantial regional diagnosis and treatment disparities, particularly in low- and middle-income countries. High-income North America had the highest rates of diagnosis, while high-income Asia Pacific showed the highest rates of treatment among diagnosed individuals. Southern Latin America had the highest rates of optimal blood sugar management among those treated. In contrast, Central sub-Saharan Africa faced the largest gaps in diagnosis, with less than 20% of people with diabetes being aware of their condition.
"By 2050, 1.3 billion people are expected to be living with diabetes, and if nearly half don't know they have a serious and potentially deadly health condition, it could easily become a silent epidemic," said Lauryn Stafford, first author and researcher at IHME.
Given the pace at which cases are rapidly rising, the research underscores the urgent need for investment in screening programs for younger populations and access to medications and glucose-monitoring tools, especially in underserved regions. In 2022, the WHO set a target to have 80% of people with diabetes clinically diagnosed by 2030.
The study was funded by the Bill & Melinda Gates Foundation.
Story Source:
Materials provided by Institute for Health Metrics and Evaluation. Note: Content may be edited for style and length.
Journal Reference:
Lauryn K Stafford, Anna Gage, Yvonne Yiru Xu, Madeleine Conrad, Ismael Barreras Beltran, Edward J Boyko, Bruce B Duncan, Simon I Hay, Hailey Lenox, Rafael Lozano, Dianna J Magliano, Carlos A Aguilar Salinas, Nikhil Tandon, Pedro Zitko, Christopher J L Murray, Theo Vos, Annie Haakenstad, Kanyin Liane Ong. Global, regional, and national cascades of diabetes care, 2000–23: a systematic review and modelling analysis using findings from the Global Burden of Disease Study. The Lancet Diabetes, 2025; DOI: 10.1016/S2213-8587(25)00217-7[1]
Cite This Page:
Institute for Health Metrics and Evaluation. "Millions have diabetes without knowing it." ScienceDaily. ScienceDaily, 15 September 2025. <www.sciencedaily.com/releases/2025/09/250914205845.htm>.
Institute for Health Metrics and Evaluation. (2025, September 15). Millions have diabetes without knowing it. ScienceDaily. Retrieved September 15, 2025 from www.sciencedaily.com/releases/2025/09/250914205845.htm
Institute for Health Metrics and Evaluation. "Millions have diabetes without knowing it." ScienceDaily. www.sciencedaily.com/releases/2025/09/250914205845.htm (accessed September 15, 2025).
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