Pochettino explains Gio Reyna's USMNT return (1:43)
Mauricio Pochettino explains why he's decided to recall Gio Reyna into his USMNT squad for the friendlies against Paraguay and Uruguay. (1:43)
CHESTER, Pennsylvania -- It had been...
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Ukrainian President Volodymyr Zelenskyy[1] announced new efforts to "clean up" the nation's energy sector amid a corruption scandal and near-constant attacks from Russia.
Zelenskyy met with Ukrainian Prime Minister Yulia
...
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From new stealth bombers to AI-enabled drones, the U.S. and China are reshaping airpower for a Pacific showdown — each betting its technology can keep the other out of the skies.
The U.S. is charging ahead with
...
Read more https://www.foxnews.com/politics/skies-stake-inside-u-s-china-race-air-dominance
Gab and Juls rate Ruben Amorim's first year at Man United (1:28)
Gab Marcotti and Julien Laurens look back on the first 12 months of Ruben Amorim's tenure as Manchester United manager. (1:28)
Nov 16, 2025, 05:20 AM ET
Juventus...
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Former first lady Michelle Obama[1] said Americans are "not ready" to elect a woman to the White House, citing former Vice President Kamala Harris' 2024 presidential election loss to President Donald Trump.
Obama made
...
The College Football Playoff selection committee's third ranking is guaranteed to look different on Tuesday night after Oklahoma's win at Alabama, but how different depends on ... Notre Dame.
The biggest question facing the group this week is how the two-loss...
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Conservative commentator Laura Loomer set off a fresh wave of speculation Saturday by openly teasing a possible move to Georgia after President Donald Trump withdrew his endorsement of Rep. Marjorie Taylor Greene in a
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As humans began to explore outer space in the latter half of the 20th century, radio waves proved a powerful tool[1]. Scientists could send out radio waves to communicate with satellites, rockets and other spacecraft, and use radio telescopes to take in
If you visit a cemetery, look closely and you’ll likely notice many flowering plants – adorning the graves, or maybe even carved into headstones.
As a horticulture Extension specialist[1] and frequent geocacher, I often visit cemeteries in urban and
When millions of people suddenly couldn’t load familiar websites and apps during the Amazon Web Services, or AWS, outage[1] on Oct. 20, 2025, the affected servers weren’t actually down. The problem was more fundamental – their names couldn’t be found.
GovernmentPolitics
As Donald Trump takes office on January 20, concerns over ‘bond vigilantes’[1] in the United States have resurfaced
Like Bill Clinton before him, Trump now faces the prospect of ‘bond vigilantes’ – so-called because they punish
Read more https://www.reutersagency.com/en/reutersbest/article/how-bond-vigilantes-could-check-trumps-power/
Technology
Reuters was first to report[1] that Meta has warned it may have to “roll back or pause” some features in India due to an antitrust directive which banned WhatsApp from sharing user data for advertising purposes. A non-public court filing seen
Business & Finance
Reuters was two-and-a-half minutes ahead[1] of rivals on Eli Lilly’s unscheduled trading update, which showed fourth-quarter sales of its weight-loss drug Zepbound would miss Wall Street estimates. The drugmaker’s shares slumped 8% on
STARBASE Maxwell, a War Department hands-on, youth science, technology, engineering, arts and mathematics outreach program at Maxwell Air Force Base, Ala., is educating thousands of students each year through immersive, inquiry-based learning.
STARBASE Maxwell, a War Department hands-on, youth science, technology, engineering, arts and mathematics outreach program at Maxwell Air Force Base, Ala., is educating thousands of students each year through immersive, inquiry-based learning.
A white paper being disseminated through the U.S. Department of War calls on Defense Secretary Pete Hegseth and top officials to adopt a broader aircraft system to replace older fleets and better aid NATO partners while sending a stronger message to adversaries, Military.com[1] has learned.
The document, shared with Military.com[2] by a source familiar with the matter, encourages the U.S. to adopt a Gulfstream G550‑based Conformal Airborne Early Warning (CAEW) platform already fielded by Israel and Italy as “a combat-proven complementary solution.” The equivalent in the United States is known as the EA-37B, an Air Force electronic warfare aircraft nicknamed “Compass Call” that uses the modified airframe of a G550 business jet but with a sensor package developed by BAE Systems.
Military.com[3] reached out to the Pentagon for comment.
The G550 model aligns with NATO’s 5% defense pledge and the 24-month Rapid Adoption Action Plan (RAAP), endorsed in June and which strives to accelerate the adoption of allies’ new defense technology, per the document.
NATO “is entering a decisive moment in airborne command and control,” the document notes, acknowledging that future architectures extending toward broader, multidomain information integration are required for modernity and properly meeting the demands of high-threat environments.
The document is reportedly moving to the desk of Hegseth, who according to sources has not yet been made privy to the document.
Boeing Remains Committed
Calls for a revamped system come as multiple NATO countries announced Thursday that they will not acquire six Boeing E-7 Wedgetail aircraft viewed as successors to Boeing E-3As—now used as AWACS (Airborne Warning and Control Systems) aircraft with an expected shelf life lasting until 2035.
“Boeing remains fully committed to NATO and allied nations’ airborne early warning and control needs,” a Boeing spokesperson told Military.com. “The E-7A is the most capable and mature AEW&C platform fielded today, with combat-proven capabilities, interoperability with alliance systems, and a ready industrial and sustainment framework to meet operational timelines.”
A Boeing official noted how In November 2023, the Boeing E-7A was selected as the only capability that meets or exceeds the airborne early warning and control requirements identified by NATO Allies.
Less Money, Better Safety
The document circulating through the Department of War calls for a NATO‑owned, European-led business jet fleet, structured under the NATO Support and Procurement Agency (NSPA). It could be jointly funded and operated to avoid current bottlenecks.
That translates to a global supply chain procuring and modifying aircraft faster than current programs allow, while also allowing for phased growth without redesigns. It would supposedly reduce sustainment costs and minimize future upgrades.
For example, a 6-8 member crew would operate a G550 at a cost of about $6,000 per hour, over a period of 8-10 hours and in a craft with higher survivability against threats.
That’s compared to a 12-14 member crew of an E7 operating at the approximate cost of $20,000 per hour, over a period of 10-12 hours and in a craft with moderate survivability against threats. The E-3 crew, described as a craft with low survivability costs a 16-20 member crew roughly $30,000 over an 8-10 hour period.
Air Solution
“This is a European-led solution in execution,” the paper states. “While the baseline airframes and some mission systems draw from U.S. and Israeli programs, conversion, certification, sustainment, and mission software can—and should—be conducted in Europe.
“That ensures political ownership, creates workshare for European industry, and opens opportunities for regional AI/ML and systems suppliers. Politically, a NATO‑owned G550 fleet would demonstrate cost-conscious burden sharing and turn the 5% pledge into tangible capability.”
Such a transition would also quantify NATO’s ability to rapidly innovate, providing reassurance to the public and a strong message of deterrence to adversaries.
“By leveraging an existing platform and allied industrial capacity, NATO can deliver a layered airborne C2 solution that complements the E‑7, enhances resilience, expands under-resourced mission areas, and proves the alliance can innovate at the speed of relevance,” the document says.
'Several Critical Gaps'
The Gulfstream G550 can close C2 gaps, per the document, and offers advantages in areas including survivability and agility, reducing vulnerability of the aircraft; improving coverage; maintaining human capital and expertise to work on newer systems; and could better be integrated across all domains.
While the E‑7 will modernize NATO’s airborne battle management, the document mentions “several critical gaps” that have been “repeatedly highlighted by senior commanders.”
They include vulnerability not just to surface‑to‑air missiles and long‑range fires but also to asymmetric threats from low-cost drones. It also describes how coverage over the High North, Baltics, Central Europe, and Black Sea is “unfeasible” with E‑7s.
There’s also concern about the timeline to have E-7s produced and distributed with the current timeline extending into the 2030s, which could leave the U.S. and NATO allies in limbo as E-3s simultaneously phase out of rotation.
“NATO’s airborne battle management advantage is at a crossroads,” the document states. “Choosing the E‑7 Wedgetail to succeed AWACS was a vital step; it is not enough. A complementary, proven platform is required to close NATO’s gaps in AEW and related mission sets.
“Distributed across Europe, it would harden wartime resilience and expand peacetime training opportunities, strengthening tomorrow’s readiness now—not a decade from now.”
NATO Partners Seek 'Alternatives'
The Netherlands are one of six NATO nations “now exploring alternatives for fleet replacement and seeking new partners,” according to a statement released by the Dutch Ministry of Defense.
In June, a senior U.S. military official announced the country’s withdrawal from the AWACS replacement program and effectively removed itself from providing strategic and financial assistance to partners. NATO has been using AWACS since 1982.
“The department is canceling the E-7 Wedgetail program due to significant delays with cost increases from $588 million to $724 million per aircraft and survivability concerns in a contested environment while investing in alternate solutions including space-based capabilities and adding additional E-2D aircraft,” the official said at the time.
The Dutch MoD said in a statement Thursday that under the previous program, both the strategic and financial foundations were lost which resulted in halting the acquisition of the E-7.
The NATO members are “now exploring alternatives for fleet replacement and seeking new partners,” per the statement.
"The goal remains to have other, quieter aircraft operational by 2035," Dutch State Defense Secretary Gijs Tuinman said. "The U.S. withdrawal also demonstrates the importance of investing as much as possible in European industry."
NATO chief Mark Rutte on Thursday signaled the urgency to "speed up” on figuring out replacements.
Military.com[4] reached out to the Dutch MoD and NATO for comment.
© Copyright 2025 Military.com. All rights reserved. This article may not be republished, rebroadcast, rewritten or otherwise distributed without written permission. To reprint or license this article or any content from Military.com, please submit your request here[5].
Have a happy and healthy holiday! Dr. Steven Gundry[1], the expert behind transformations from stars like Kelly Clarkson[2] and Usher[3], is sharing his top wellness tips[4] with ET just in time for the 2026 holiday season.
Before you hit a holiday party,
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Feeling grateful! alice + olivia just dropped its second collaboration[1] with the Grateful Dead, honoring 60 years of the legendary band in true rock 'n roll fashion on Wednesday, Nov. 12, at Angel Orensanz in New York City.
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The chic brand, loved by
Flawless from head to toe! Manucurist[1] founder Gaëlle Lebrat Personnaz wants you to treat your nails like your skin, and celebs like Jennifer Lopez[2], Hailey Bieber[3], Margot Robbie[4], and Gwyneth Paltrow[5] have already gotten the memo.
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Not only do
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Ukrainian President Volodymyr Zelenskyy[1] announced new efforts to "clean up" the nation's energy sector amid a corruption scandal and near-constant attacks from Russia.
Zelenskyy met with Ukrainian Prime Minister Yulia
...
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From new stealth bombers to AI-enabled drones, the U.S. and China are reshaping airpower for a Pacific showdown — each betting its technology can keep the other out of the skies.
The U.S. is charging ahead with
...
Read more https://www.foxnews.com/politics/skies-stake-inside-u-s-china-race-air-dominance
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Former first lady Michelle Obama[1] said Americans are "not ready" to elect a woman to the White House, citing former Vice President Kamala Harris' 2024 presidential election loss to President Donald Trump.
Obama made
...
More than 50,000 people in the UK each month get a private prescription for medical cannabis....
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An experimental compound has been found to limit cell death, reduce inflammation, and lessen organ damage associated with diabetes.
A research team at NYU Langone Health reported that, in mouse studies, a drug candidate successfully prevented two proteins from interacting: RAGE and DIAPH1. When these proteins come together, they contribute to heart and kidney injury linked to diabetes and slow the healing of wounds.
Blocking a Key Protein Interaction Boosts Healing
The findings, recently featured as a cover story in Cell Chemical Biology, show that keeping DIAPH1 from attaching to RAGE can ease swelling in diabetic tissues and promote more efficient repair. Tests conducted in human cells and mouse models revealed that the compound significantly reduced both immediate and long-term complications in Type 1 and Type 2 diabetes. The compound, known as RAGE406R, is a small molecule named for the protein it targets.
"There are currently no treatments that address the root causes of diabetic complications, and our work shows that RAGE406R can -- not by lowering the high blood sugar, but instead by blocking the intracellular action of RAGE," said co-senior study author Ann Marie Schmidt, MD, the Dr. Iven Young Professor of Endocrinology at the NYU Grossman School of Medicine. "If confirmed by further testing in human trials, the compound could potentially fill gaps in treatment, including that most current drugs work only against Type 2 diabetes."
How RAGE and DIAPH1 Contribute to Damage
RAGE is a receptor, a type of protein that responds to signaling molecules known as advanced glycation end products (AGEs). These molecules form when proteins or fats bind to sugars, a process that occurs more frequently in people with diabetes. AGEs accumulate in the bloodstream in individuals with diabetes and obesity, and also naturally increase with age.
Experiments showed that RAGE406R competes for the binding site on RAGE that DIAPH1 normally occupies. DIAPH1 helps form actin filaments, which are part of the cell's internal structure. The researchers demonstrated that DIAPH1 connects to the inner tail of RAGE, and this pairing increases the formation of actin structures that intensify diabetic complications.
Developing a Safer and More Effective Molecule
Schmidt's team previously screened a library of more than 58,000 molecules and identified several that interfered with the RAGE-DIAPH1 pathway. Their earlier lead compound, RAGE229, did not pass a standard safety test designed to flag structural features that might alter DNA and raise cancer risk. RAGE406R removes the part of the structure that created this concern.
The team then tested RAGE406R in a widely used model for chronic diabetes complications: delayed wound healing in obese mice with Type 2 diabetes. In both male and female mice, applying RAGE406R directly to the skin accelerated wound closure.
Reducing Misplaced Inflammation to Support Repair
Many of the compound's benefits stem from its effects on the immune system. The immune response is designed to detect and eliminate harmful invaders such as bacteria and viruses. When activated, it can cause inflammation, which includes swelling triggered by immune cells gathering at an injured area. In diabetes, inflammation often occurs in the wrong places or lasts too long.
RAGE406R lowered the levels of CCL2, a major proinflammatory signaling molecule. Reducing CCL2 activity calmed inflammation in macrophages, a type of immune cell. This shift helped support structural remodeling in tissues, an essential part of the healing process.
"Our findings point to a promising new pathway for treating diabetes in the future," said co-senior study author Alexander Shekhtman, PhD, a professor in the Department of Chemistry at the State University of New York (SUNY) at Albany. "The current study results serve as a springboard for the development of therapies for both types of diabetes, and for designing markers that can measure how well the new treatment works in live animals."
Contributors and Funding Support
Along with Schmidt, contributors from the Diabetes Research Program in the Department of Medicine at NYU Langone Health include co-first author Michaele Manigrasso, as well as Gautham Yepuri, Kaamashri Mangar, and Ravichandran Ramasamy. Additional NYU Langone collaborators include Sally Vanegas from the Department of Medicine and Yanan Zhao and Huilin Li from the Division of Biostatistics in the Department of Population Health. Shekhtman's group at SUNY at Albany includes first author Gregory Theophall, Parastou Nazarian, Aaron Premo, Sergey Reverdatto, and David Burz. Robert DeVita, PhD, from RJD Medicinal Chemistry and Drug Discovery Consulting LLC, also contributed to the research.
This work was funded by U.S. Public Health Service grants 1R24DK103032, 1R01DK122456-01A1, P01HL146367, and 5R01GM085006. The NYU Histology Core receives partial support from the Perlmutter Cancer Center support grant P30CA016087. Additional backing came from the Diabetes Research Program at the NYU Grossman School of Medicine. Drs. Manigrasso, Ramasamy, and Schmidt are listed on patent applications owned by NYU Langone Health related to this research. Their relationship to this intellectual property is being managed in accordance with NYU Langone Health policies. Dr. DeVita, who consults for NYU Technology Opportunities & Ventures' Therapeutics Alliances and for Intercept Therapeutics, was compensated for his involvement.
For Sophie Richards those early conversations were just part of the daunting prospect of finding love when you have endometriosis....
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NFL Madrid Game
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Nov 16, 2025, 07:54 AM ET
DUBAI, United Arab Emirates -- Rory McIlroy[1]'s banner year ended with more drama Sunday when he eagled the last hole in regulation to force a playoff but lost out to Matt Fitzpatrick[2], who won the season-closing...
NEW YORK -- The UFC has banned Dillon Danis[1], a former training partner of MMA superstar Conor McGregor[2], from future events, according to UFC CEO Dana White.
Danis was involved in a brawl with several members of UFC champion Islam Makhachev...
Read more https://www.espn.com/mma/story/_/id/46985000/danis-banned-ufc-crowd-brawl-msg-white-says
Everyone has looked up at the clouds and seen faces, animals, objects. Human brains are hardwired[1] for this kind of whimsy. But some people – perhaps a surprising number[2] – look to the sky and see government plots and wicked deeds written there. Conspiracy theorists say that contrails[3] – long streaks of condensation left by...
Blue Origin’s New Glenn rocket successfully made its way to orbit[1] for the second time on Nov. 13, 2025. Although the second launch is never as flashy as the first, this mission is still significant in several ways.
For one, it launched a pair of NASA spacecraft named ESCAPADE[2], which are headed to Mars orbit[3] to study that...
China’s Shenzhou-20 spacecraft took a hit[1] from a piece of space debris floating through orbit, causing Chinese officials to delay the spacecraft’s return from its Tiangong space station in early November 2025.
In addition to stranding the three Chinese astronauts – called taikonauts – who were set to return to Earth, this incident...
"You shall not covet your neighbor's house. You shall not covet your neighbor's wife, or his manservant or maidservant, his ox or donkey, or anything that belongs to your neighbor." Exodus 20:1-17.
That is, just look at your own piece of the pie, not the other fellow’s. You will look at what you have, not what someone else has. You will not act upon a desire for something that belongs to someone else. What's your is yours, what's theirs is theirs. You will focus on your property, not their property. It is not about them and what they have; it is about you, your journey toward God, and what you have along the way.
Why would God require this?
Implementing this commandment yields a certain kind of social structure. Not following it creates another. And the social structure in which people grow up and live their lives affects how people are trained up for God.
What are the practical consequences of this?
The primitive hate on display in the streets around the globe cries out for a Final Solution to the Jewish Problem.
It is time to end the Jewish Problem once and for all.
Both the problem and solution are simple, and this instruction can be short.
The decision and responsibility for it are yours.
First one bank announced it will only accept digital currency.
Now the Reserve Bank of Australia has announced it is heading into digital currency.
As the moth is to the flame, so are the follies of man.
Artificial intelligence and the next level of quantum computing will render passwords and encryption efforts obsolete.
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