Each October, the Nobel Prizes celebrate a handful of groundbreaking scientific achievements. And while many of the awarded discoveries revolutionize the field of science, some originate in unconventional places. For George de Hevesy[1], the 1943 Nobel Laureate in chemistry who discovered radioactive tracers, that place was a boarding house cafeteria in Manchester, U.K., in 1911.

A black and white headshot of a young man with a mustache wearing a suit.
Hungarian chemist George de Hevesy. Magnus Manske[2]

De Hevesey had the sneaking suspicion that the staff of the boarding house cafeteria where he ate at every day was reusing leftovers from the dinner plates – each day’s soup seemed to contain all of the prior day’s ingredients. So he came up with a plan to test his theory.

At the time, de Hevesy was working with radioactive material. He sprinkled a small amount[3] of radioactive material in his leftover meat. A few days later, he took an electroscope with him to the kitchen and measured the radioactivity[4] in the prepared food.

His landlady, who was to blame for the recycled food, exclaimed “this is magic” when de Hevesy showed her his results, but really, it was just the first successful radioactive tracer experiment.

We are[5] a team of chemists[6] and physicists who work[7] at the Facility for Rare Isotope Beams[8], located at Michigan State University. De Hevesy’s early research in the field has revolutionized the way that modern scientists like us use radioactive material, and it has led to a variety of scientific and medical advances.

The nuisance of lead

A year before conducting his recycled ingredients experiment, Hungary-born de Hevesy had traveled to the U.K.[9] to start work with nuclear scientist Ernest Rutherford[10], who’d won a Nobel Prize just two years prior.

Rutherford was at the time working with a radioactive substance[11] called radium D, a valuable byproduct of radium because of its long half-life[12] (22 years). However, Rutherford couldn’t use his radium D sample, as it had large amounts of lead mixed in.

When de Hevesy arrived, Rutherford asked him to separate the radium D[13] from the nuisance lead. The nuisance lead was made up of a combination of stable isotopes of lead (Pb). Each isotope had the same number of protons (82 for lead), but a different number of neutrons.

De Hevesy worked on separating the radium D from the natural lead using chemical separation techniques for almost two years, with no success[14]. The reason for his failure was that, unknown to anyone at the time, radium D was actually a different form of lead – namely the radioactive isotope, or radioisotope Pb-210.

Nevertheless, de Hevesy’s failure led to an even bigger discovery. The creative scientist figured out that if he could not separate radium D from natural lead, he could use it as a tracer of lead.

Radioactive isotopes[15], like Pb-210, are unstable isotopes, which means that over time they will transform into a different element. During this transformation, called radioactive decay, they typically release particles or light, which can be detected as radioactivity[16].

Through radioactivity, an unstable isotope can turn from one element to another.

This radioactivity acts as a signature indicating the presence of the radioactive isotope. This critical property of radioisotopes allows them to be used as tracers.

Radium D as a tracer

A tracer[17] is a substance that stands out in a crowd of similar material because it has unique qualities that make it easy to track.

For example, if you have a group of kindergartners going on a field trip and one of them is wearing a smartwatch, you can tell if the group went to the playground by tracking the GPS signal on the smartwatch. In de Hevesy’s case, the kindergartners were the lead atoms, the smart watch was radium D, and the GPS signal was the emitted radioactivity.

In the 1910s, the Vienna Institute of Radium Research[18] had a larger collection of radium[19] and its byproducts than any other institution. To continue his experiments with radium D, de Hevesy moved to Vienna in 1912.

He collaborated with Fritz Paneth, who had also attempted the impossible task of separating radium D from lead without success. The two scientists “spiked” samples of different chemical compounds with small amounts of a radioactive tracer. This way they could study chemical processes by tracking the movement of the radioactivity across different chemical reactions[20]

De Hevesy continued his work studying chemical processes using different isotopic markers for many years. He even was the first to introduce nonradioactive tracers. One nonradioactive tracer he studied was a heavier isotope of hydrogen, called deuterium[21]. Deuterium is 10,000 times less abundant than common hydrogen, but is roughly twice as heavy, which makes it easier to separate the two.

De Hevesy and his co-author used deuterium to track water in their bodies. In their investigations, they took turns ingesting samples and measuring the deuterium in their urine to study the elimination of water[22] from the human body.

De Hevesy was awarded the 1943 Nobel Prize in chemistry[23] “for his work on the use of isotopes as tracers in the study of chemical processes.”

Radioactive tracers today

More than a century after de Hevesy’s experiments, many fields now routinely use radioactive tracers, from medicine to materials science and biology.

These tracers can monitor the progression of disease in medical procedures[24], the uptake of nutrients in plant biology[25], the age and flow of water in aquifers[26] and the measurement of wear and corrosion of materials[27], among other applications. Radioisotopes allow researchers to follow the paths of nutrients and drugs in living systems without invasively cutting the tissue.

Four brain scans, two in contrasted colors with the background shown as white and the brain as gray, two with the background shown as black and the brain shown either as gray or orange.
Radioactive tracers, seen in the top left photo as a white spot and indicated by an arrow in the top right, are often used today in brain scans. mr. suphachai praserdumrongchai/iStock via Getty Images[28]

In modern research, scientists focus on producing new isotopes and on developing procedures to use radioactive tracers more efficiently. The Facility for Rare Isotope Beams[29], or FRIB, where the three of us work, has a program dedicated to the production and harvesting of unique radioisotopes. These radioisotopes are then used in medical and other applications.

FRIB produces radioactive beams[30] for its basic science program. In the production process, a large number of unused isotopes are collected in a tank of water, where they can be later isolated and studied[31].

Two scientists, a woman wearing a white shirt and a man wearing a dark blue shirt, squat on the concrete ground in a laboartory with lots of machinery and shelves, and a green lit ceiling.
Scientists Greg Severin and Katharina Domnanich at the Facility for Rare Isotope Beams. Facility for Rare Isotope Beams.

One recent study involved the isolation of the radioisotope Zn-62[32] from the irradiated water. This was a challenging task considering there were 100 quadrillion times more water molecules than Zn-62 atoms. Zn-62 is an important radioactive tracer utilized to follow the metabolism of zinc in plants and in nuclear medicine.

Eighty years ago, de Hevesy managed to take a dead-end separation project and turn it into a discovery that created a new scientific field. Radioactive tracers have already changed human lives in so many ways. Nevertheless, scientists are continuing to develop new radioactive tracers and find innovative ways to use them.

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The 2023 Nobel Prize for chemistry isn’t the[1] first Nobel[2] awarded for[3] research in[4] nanotechnology[5]. But it is perhaps the most colorful application of the technology to be associated with the accolade.

This year’s prize recognizes Moungi Bawendi[6], Louis Brus[7] and Alexei Ekimov[8] for the discovery and development of quantum dots[9]. For many years, these precisely constructed nanometer-sized particles[10] – just a few hundred thousandths the width of a human hair in diameter – were the darlings of nanotechnology pitches and presentations. As a researcher[11] and adviser[12] on nanotechnology, I’ve even used them myself[13] when talking with developers, policymakers, advocacy groups and others about the promise and perils of the technology.

The origins of nanotechnology predate Bawendi, Brus and Ekimov’s work on quantum dots – the physicist Richard Feynman speculated on what could be possible through nanoscale engineering as early as 1959[14], and engineers like Erik Drexler were speculating about the possibilities of atomically precise manufacturing in the the 1980s[15]. However, this year’s trio of Nobel laureates were part of the earliest wave of modern nanotechnology where researchers began putting breakthroughs in material science to practical use[16].

Quantum dots brilliantly fluoresce[17]: They absorb one color of light and reemit it nearly instantaneously as another color. A vial of quantum dots, when illuminated with broad spectrum light, shines with a single vivid color. What makes them special, though, is that their color is determined by how large or small they are. Make them small and you get an intense blue. Make them larger, though still nanoscale, and the color shifts to red.

diagram of colorful circles of different sizes
The wavelength of light a quantum dot emits depends on its size. Maysinger, Ji, Hutter, Cooper[18], CC BY[19]

This property has led to many arresting images of rows of vials containing quantum dots of different sizes going from a striking blue on one end, through greens and oranges, to a vibrant red at the other. So eye-catching is this demonstration of the power of nanotechnology that, in the early 2000s, quantum dots became iconic of the strangeness and novelty of nanotechnology.

But, of course, quantum dots are more than a visually attractive parlor trick. They demonstrate that unique, controllable and useful interactions between matter and light can be achieved through engineering the physical form of matter – modifying the size, shape and structure of objects or instance – rather than playing with the chemical bonds between atoms and molecules. The distinction is an important one, and it’s at the heart of modern nanotechnology.

Skip chemical bonds, rely on quantum physics

The wavelengths of light that a material absorbs, reflects or emits are usually determined by the chemical bonds that bind its constituent atoms together. Play with the chemistry of a material[20] and it’s possible to fine-tune these bonds so that they give you the colors you want. For instance, some of the earliest dyes started with a clear substance such as analine[21], transformed through chemical reactions to the desired hue.

It’s an effective way to work with light and color, but it also leads to products that fade over time as those bonds degrade[22]. It also frequently involves using chemicals that are harmful to humans and the environment[23].

Quantum dots work differently. Rather than depending on chemical bonds to determine the wavelengths of light they absorb and emit, they rely on very small clusters of semiconducting materials[24]. It’s the quantum physics of these clusters[25] that then determines what wavelengths of light are emitted – and this in turn depends on how large or small the clusters are.

This ability to tune how a material behaves by simply changing its size is a game changer when it comes to the intensity and quality of light that quantum dots can produce, as well as their resistance to bleaching or fading, their novel uses and – if engineered smartly – their toxicity.

Of course, few materials are completely nontoxic, and quantum dots are no exception. Early quantum dots were often based on cadmium selenide for instance – the component materials of which are toxic. However, the potential toxicity of quantum dots needs to be balanced[26] by the likelihood of release and exposure and how they compare with alternatives.

people walk past colorful multi-screen display at a trade show
Quantum dots are now a normal part of many consumer items, including televisions. Soeren Stache/picture alliance via Getty Images[27]

Since its earlier days, quantum dot technology has evolved in safety and usefulness and has found its way into an increasing number of products, from displays[28] and lighting[29], to sensors[30], biomedical applications[31] and more. In the process, some of their novelty has perhaps worn off. It can be hard to remember just how much of a quantum leap the technology is that’s being used to promote the latest generation of flashy TVs[32], for instance.

And yet, quantum dots are a pivotal part of a technology transition that’s revolutionizing how people work with atoms and molecules.

‘Base coding’ on an atomic level

In my book “Films from the Future: the Technology and Morality of Sci-Fi Movies[33],” I write about the concept of “base coding[34].” The idea is simple: If people can manipulate the most basic code that defines the world we live in, we can begin to redesign and reengineer it.

This concept is intuitive when it comes to computing, where programmers use the “base code” of 1,s and 0’s, albeit through higher level languages. It also makes sense in biology, where scientists are becoming increasingly adept at reading and writing the base code of DNA and RNA – in this case, using the chemical bases adenine, guanine, cytosine and thymine as their coding language.

This ability to work with base codes also extends to the material world. Here, the code is made up of atoms and molecules and how they are arranged in ways that lead to novel properties.

Bawendi, Brus and Ekimov’s work on quantum dots is a perfect example of this form of material-world base coding. By precisely forming small clusters of particular atoms into spherical “dots,” they were able to tap into novel quantum properties that would otherwise be inaccessible. Through their work they demonstrated the transformative power that comes through coding with atoms.

alt
An example of ‘base coding’ using atoms to create a material with novel properties is a single molecule ‘nanocar’ crafted by chemists that can be controlled as it ‘drives’ over a surface. Alexis van Venrooy/Rice University[35], CC BY-ND[36]

They paved the way for increasingly sophisticated nanoscale base coding that is now leading to products and applications that would not be possible without it. And they were part of the inspiration for a nanotechnology revolution[37] that is continuing to this day. Reengineering the material world in these novel ways far transcends what can be achieved through more conventional technologies.

This possibility was captured in a 1999 U.S. National Science and Technology Council report with the title Nanotechnology: Shaping the World Atom by Atom[38]. While it doesn’t explicitly mention quantum dots – an omission that I’m sure the authors are now kicking themselves over – it did capture just how transformative the ability to engineer materials at the atomic scale could be.

This atomic-level shaping of the world is exactly what Bawendi, Brus and Ekimov aspired to through their groundbreaking work. They were some of the first materials “base coders” as they used atomically precise engineering to harness the quantum physics of small particles – and the Nobel committee’s recognition of the significance of this is well deserved.

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Electrons moving around in a molecule might not seem like the plot of an interesting movie. But a group of scientists will receive the 2023 Nobel Prize in physics[1] for research that essentially follows the movement of electrons[2] using ultrafast laser pulses, like capturing frames in a video camera.

However, electrons, which partly make up atoms[3] and form the glue that bonds atoms in molecules together, don’t move around on the same time scale people do. They’re much faster. So, the tools that physicists like me[4] use to capture their motion have to be really fast – attosecond-scale fast.

One attosecond[5] is one billionth of a billionth of a second (10⁻¹⁸ second) – the ratio of one attosecond to one second is the same as the ratio of one second to the age of the universe.

Attosecond pulses

In photography, capturing clear images of fast objects requires a camera with a fast shutter[6] or a fast strobe of light to illuminate the object. By taking multiple photos in quick succession, the motion of the object can be clearly resolved.

The time scale of the shutter or the strobe must match the time scale of motion of the object – if not, the image will be blurred. This same idea applies when researchers attempt to image the ultrafast motion of electrons[7]. Capturing attosecond-scale motion requires an attosecond strobe. The 2023 Nobel laureates in physics[8] made seminal contributions to the generation of such attosecond laser strobes, which are very short pulses generated using a powerful laser.

Imagine the electrons in an atom are constrained within the atom by a wall. When a femtosecond (10⁻¹⁵ second) laser pulse from a high-powered femtosecond laser is directed at atoms of a noble gas such as argon, the strong electric field in the pulse lowers the wall.

This is possible because the laser electric field is comparable in strength to the electric field of the nucleus of the atom. Electrons see this lowered wall and pass through in a bizarre process called quantum tunneling[9].

As soon as the electrons exit the atom, the laser’s electric field captures them, accelerates them to high energies and slams them back into their parent atoms. This process of recollision results in creation of attosecond bursts of laser light.

A diagram showing how electrons gain, then release energy when exposed to a laser's electric field, with a pink arrow showing the laser's energy and small drawings of spheres stuck together indicating the atom.
A laser’s electric field allows electrons to escape from the atom, gain energy and then release energy as they’re reabsorbed back into the atom. Johan Jarnestad/The Royal Swedish Academy of Sciences[10], CC BY-NC-ND[11]

Attosecond movies

So how do physicists use these ultrashort pulses to make movies of electrons at the attosecond scale?

Conventional movies are made one scene at a time, with each instant captured as a frame with video cameras. The scenes are then stitched together to form the complete movie.

Attosecond movies of electrons use a similar idea. The attosecond pulses act as strobes, lighting up the electrons so researchers can capture their image, over and over again as they move – like a movie scene. This technique is called pump-probe spectroscopy[12].

However, imaging electron motion directly inside atoms is currently challenging, though researchers are developing several approaches using advanced microscopes to make direct imaging possible[13].

Typically, in pump-probe spectroscopy, a “pump” pulse gets the electron moving and starts the movie. A “probe” pulse then lights up the electron at different times after the arrival of the pump pulse, so it can be captured by the “camera,” such as a photoelectron spectrometer[14].

Pump-probe spectroscopy.

The information on the motion of electrons, or the “image,” is captured using sophisticated techniques. For example, a photoelectron spectrometer detects how many electrons were removed from the atom by the probe pulse, or a photon spectrometer[15] measures how much of the probe pulse was absorbed by the atom.

The different “scenes” are then stitched together to make the attosecond movies of electrons. These movies help provide fundamental insight, with help from sophisticated theoretical models[16], into attosecond electronic behavior.

For example, researchers have measured where the electric charge is located[17] in organic molecules at different times, on attosecond time scales. This could allow them to control electric currents on the molecular scale.

Future applications

In most scientific research, fundamental understanding of a process leads to control of the process, and such control leads to new technologies. Curiosity-driven research[18] can lead to unimaginable applications in the future, and attosecond science is likely no different.

Understanding and controlling the behavior of electrons on the attosecond scale could enable researchers to use lasers to control chemical reactions[19] that they can’t by other means. This ability could help engineer new molecules that cannot be created with existing chemical techniques.

The ability to modify electron behavior could lead to ultrafast switches. Researchers could potentially convert an electric insulator to a conductor on attosecond scales[20] to increase the speed of electronics. Electronics currently process information at the picosecond scale, or 10⁻¹² of a second.

The short wavelength of attosecond pulses, which is typically in the extreme-ultraviolet, or EUV, regime, may see applications in EUV lithography[21] in the semiconductor industry. EUV lithography uses laser light with a very short wavelength to etch tiny circuits on electronic chips.

A line of silver pipes and machinery, in a bright room, with red and blue handles.
The Linac Coherent Light Source at SLAC National Accelerator Laboratory. Department of Energy[22], CC BY[23]

In the recent past, free-electron lasers such as the Linac Coherent Light Source[24] at SLAC National Accelerator Laboratory in the United States have emerged as a source of bright X-ray laser light. These now generate pulses on the attosecond scale, opening many possibilities for research using attosecond X-rays.

Ideas to generate laser pulses on the zeptosecond (10⁻²¹ second) scale have also been proposed. Scientists could use these pulses, which are even faster than attosecond pulses, to study the motion of particles like protons within the nucleus.

With numerous research groups actively working on exciting problems in attosecond science, and with 2023’s Nobel Prize in physics[25] recognizing its importance, attosecond science has a long and bright future.

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Elon Musk’s vision of Twitter, now rebranded as X, as an “everything app”[1] is no secret. When the X logo replaced Twitter’s blue bird[2], the internet buzzed with heated discussions[3] about just what it would mean for X to be an everything app.

Musk promoted his super app project by referring to the Chinese all-in-one app WeChat[4]. But for many American users unfamiliar with WeChat, a train of questions followed. What’s it like to use WeChat? How has WeChat become “everything” in China? Would it be possible to replicate the app’s success in the U.S.[5]?

I’m a Chinese digital media scholar[6], and I’ve used WeChat since 2012. But, in contrast to Musk’s enthusiasm, I don’t think WeChat is something to write home about. I believe it’s ordinary rather than special, lacking distinctive features compared with the other popular apps I studied for my current book project about Chinese touchscreen media.

WeChat’s inconspicuousness on my phone screen is no accident. Although WeChat is an everything app in the sense of being a digital hub for over a billion users, the app’s design is intentionally grounded in a more nuanced and philosophical meaning of the word “everything” than you might expect.

WeChat is an all-inclusive media ecosystem

Launched in 2011, WeChat[7] has become an all-in-one app that offers services covering most aspects of everyday life, from instant messaging and mobile payments to photo- and video-sharing social networking. It has become a staple of daily activities for 1.3 billion Chinese mobile users[8].

WeChat is also the app that China-bound travelers can download if they want to install only one app. WeChat can help you fill out customs declaration forms, call a taxi, pay for your hotel room and order food. Without WeChat, a traveler in China would be like a fish out of water[9], since everything in China now runs through smartphone screens and mobile payment platforms.

A smart phone screen displaying a messaging app with Chinese text
A smartphone displays WeChat’s group-messaging function. Ou Dongqu/Xinhua via Getty Images[10]

In this sense, WeChat is indeed an everything app. Its “everythingness” refers to its near omnipresence and omnipotence in everyday life. The app creates an all-encompassing and ever-expanding media ecosystem that influences users’ daily activities. It forms a gigantic digital hub that, as German philosopher and media theorist Peter Sloterdijk once described[11], “has drawn inwards everything that was once on the outside.”

This “everythingness” leaves little room for rival companies to achieve similar dominance and turns every tap or swipe on a user’s smartphone into something a big tech company can profit from. This dream of an internet empire is perhaps what is so enticing for tech leaders like Musk[12].

A counterintuitive design philosophy

Despite WeChat’s status as an everything app, it’s one of the least notable and attractive apps on my smartphone. WeChat rarely changes its logo to celebrate holidays or sends admin notifications to users. The app forms a relatively closed social space, since WeChat users can see only what their contacts post, unlike apps like Weibo[13] or TikTok[14], where celebrities amass millions of followers.

graphic of a small figure of a person against a large moon-like orb
WeChat’s splash screen is visually clean and has been unchanged for a decade. Screen capture by Jianqing Chen

But the lack of flashy, attention-grabbing features is actually one of WeChat’s intentional design philosophies, as WeChat’s founder and chief developer Allen Xiaolong Zhang made clear in his annual public speeches in 2019 and 2020[15]. Zhang emphasized that one of WeChat’s design principles is to “get users out of the app as fast as possible,” meaning to reduce the amount of time users spend in WeChat.

This might seem paradoxical – if WeChat is trying to get its users to leave the app as fast as possible, how can it maintain its internet empire? Typically an app’s popularity is assessed based on how long users spend in the app, and users’ attention is the scarce resource[16] various digital platforms fight for.

But Zhang claims that in order to sustain users’ daily engagement with the app in the long run, it’s important to let them leave the app as fast as possible. A low demand for time and effort is key to bringing users back into the app without exhausting them.

A Taoist message behind WeChat’s design

The design of WeChat miniprograms[17] makes Zhang’s idea clear. Miniprograms are embedded into WeChat as third-party developed sub-applications, and they provide users with easy access to a large range of services – like hailing a taxi, ordering food, buying train tickets and playing games – without leaving WeChat. Users can simply search in the app or scan a QR code to open a miniprogram, skipping the cumbersome processes of installing and uninstalling new apps.

A screenshot of a smartphone homepage, with round circular apps and text in Chinese
WeChat has a panel of miniprograms that users pull down from the top of the screen. Screen capture by Jianqing Chen, CC BY-ND[18]

Miniprograms are stored in a hidden panel at the top of the screen. They can be opened by swiping down the screen. These miniprograms appear to be ephemeral, diffusive and almost atmospheric. They give users the feeling that WeChat has disappeared or merged into the environment.

WeChat is what media scholars call “elemental[19]”: inconspicuous and nonintrusive, yet pervasive and as fundamental as the natural elements, just like air, water and clouds.

This environment of pervasiveness and unobtrusiveness resonates with the ancient Chinese Taoist philosophy that understands nothing (wu 无, or “not-being”) as that which forms the basis of all things (wanwu 万物 or “ten thousand things”). As Tao Te Ching states[20], “Dao begets One (or nothingness), One begets Two (yin and yang), Two begets Three (Heaven, Earth and Man; or yin, yang and breath qi), Three begets all things.” For Taoist thinkers, not-being determines how all things within the cosmos come into being, evolve and disappear.

Although the depth of these sagely texts is unfathomable, the Taoist thoughts from the past help people appreciate the interplay of everything and nothing. This perspective adds another layer of meaning to “everything” and opens up alternative visions of what an everything app can be.

Perhaps WeChat’s interpretation of the word “everything” – as simultaneously pervasive and inconspicuous – is the secret to its success over the past 10 years. I believe many tech leaders could benefit from a more sophisticated understanding of “everything” when envisioning the everything app, and not just equate “everything” simply with big and comprehensive.

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Living cells work better than dying cells, right? However, this is not always the case: your cells often sacrifice themselves to keep you healthy[1]. The unsung hero of life is death.

While death may seem passive, an unfortunate ending that just “happens,” the death of your cells is often extremely purposeful and strategic. The intricate details of how and why cells die can have significant effects on your overall health.

There are over 10 different ways cells can “decide” to die, each serving a particular purpose for the organism. My own research[2] explores how immune cells switch between different types of programmed death in scenarios like cancer or injury.

Programmed cell death can be broadly divided into two types[3] that are crucial to health: silent and inflammatory.

Quietly exiting: silent cell death

Cells can often become damaged because of age, stress or injury, and these abnormal cells can make you sick[4]. Your body runs a tight ship, and when cells step out of line, they must be quietly eliminated before they overgrow into tumors or cause unnecessary inflammation[5] where your immune system is activated and causes fever, swelling, redness and pain.

Your body swaps out cells every day[6] to ensure that your tissues are made up of healthy, functioning ones. The parts of your body that are more likely to see damage, like your skin and gut, turn over cells weekly, while other cell types can take months to years to recycle. Regardless of the timeline, the death of old and damaged cells and their replacement with new cells is a normal and important bodily process.

Silent cell death, or apoptosis[7], is described as silent because these cells die without causing an inflammatory reaction. Apoptosis is an active process involving many proteins and switches within the cell. It’s designed to strategically eliminate cells without alarming the rest of the body.

Sometimes cells can detect that their own functions are failing and turn on executioner proteins[8] that chop up their own DNA, and they quietly die by apoptosis. Alternatively, healthy cells can order overactive or damaged neighbor cells to activate their executioner proteins.

Apoptosis is important to maintaining a healthy body. In fact, you can thank apoptosis for your fingers and toes[9]. Fetuses initially have webbed fingers until the cells that form the tissue between them undergo apoptosis and die off.

Microscopy image of mouse foot at embryonic stage
The toes of this embryonic mouse foot are forming through apoptosis. Michal Maňas/Wikimedia Commons[10], CC BY-SA[11]

Without apoptosis, cells can grow out of control. A well-studied example of this is cancer. Cancer cells are abnormally good at growing and dividing, and those that can resist apoptosis[12] form very aggressive tumors. Understanding how apoptosis works and why cancer cells can disrupt it can potentially improve cancer treatments.

Other conditions can benefit from apoptosis research as well. Your body makes a lot of immune cells that all respond to different targets, and occasionally one of these cells can accidentally target your own tissues. Apoptosis is a crucial way your body can eliminate these immune cells before they cause unnecessary damage. When apoptosis fails to eliminate these cells, sometimes because of genetic abnormalities, this can lead to autoimmune diseases[13] like lupus.

Another example of the role apoptosis plays in health is endometriosis[14], an understudied disease caused by the overgrowth of tissue in the uterus. It can be extremely painful and debilitating for patients. Researchers have recently linked this out-of-control growth in the uterus[15] to dysfunctional apoptosis.

Whether it’s for development or maintenance, your cells are quietly exiting to keep your body happy and healthy.

Going out with a bang: inflammatory cell death

Sometimes, it is in your body’s best interest for cells to raise an alarm as they die. This can be beneficial when cells detect the presence of an infection and need to eliminate themselves as a target while also alerting the rest of the body. This inflammatory cell death[16] is typically triggered by bacteria, viruses or stress.

Rather than quietly shutting down, cells undergoing inflammatory cell death will make themselves burst, or lyse, killing themselves and exploding inflammatory messengers as they go. These messengers tell your immune cells that there is a threat and prompts them to treat and fight the pathogen.

An inflammatory death would not be healthy for maintenance. If the normal recycling of your skin or gut cells caused an inflammatory reaction, you would feel sick a lot. This is why inflammatory death is tightly controlled[17] and requires multiple signals to initiate.

Despite the riskiness of this grenadelike death, many infections would be impossible to fight without it. Many bacteria and viruses need to live around or inside your cells to survive. When specialized sensors on your cells detect these threats, they can simultaneously activate your immune system and remove themselves as a home for pathogens. Researchers call this eliminating the niche[18] of the pathogen.

Cells die in many ways, including lysis.

Inflammatory cell death plays a major role in pandemics. Yersinia pestis[19], the bacteria behind the Black Death, has evolved various ways of stopping human immune cells from mounting a response. However, immune cells developed the ability to sense this trickery and die an inflammatory death. This ensures that additional immune cells will infiltrate and eliminate the bacteria despite the bacteria’s best attempts to prevent a fight.

Although the Black Death is not as common nowadays, close relatives Yersinia pseudotuberculosis and Yersinia enterocolitica are behind outbreaks of food-borne illnesses[20]. These infections are rarely fatal because your immune cells can aggressively eliminate the pathogen’s niche by inducing inflammatory cell death. For this reason, however, Yersinia infection can be more dangerous in immunocompromised people.

The virus behind the COVID-19 pandemic[21] also causes a lot of inflammatory cell death. Studies show that without cell death the virus would freely live inside your cells and multiply. However, this inflammatory cell death can sometimes get out of control and contribute to the lung damage[22] seen in COVID-19 patients, which can greatly affect survival. Researchers are still studying the role of inflammatory cell death in COVID-19 infection, and understanding this delicate balance can help improve treatments.

In good times and bad, your cells are always ready to sacrifice themselves to keep you healthy. You can thank cell death for keeping you alive.

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A group of three researchers earned the 2023 Nobel Prize in physics[1] for work that has revolutionized how scientists study the electron – by illuminating molecules with attosecond-long flashes of light. But how long is an attosecond, and what can these infinitesimally short pulses tell researchers about the nature of matter?

I first learned[2] of this area of research as a graduate student in physical chemistry. My doctoral adviser’s group had a project dedicated to studying chemical reactions with attosecond pulses[3]. Before understanding why attosecond research resulted in the most prestigious award in the sciences, it helps to understand what an attosecond pulse of light is.

How long is an attosecond?

“Atto” is the scientific notation prefix[4] that represents 10⁻¹⁸, which is a decimal point followed by 17 zeroes and a 1. So a flash of light lasting an attosecond, or 0.000000000000000001 of a second, is an extremely short pulse of light.

In fact, there are approximately as many attoseconds in one second as there are seconds in the age of the universe[5].

A diagram showing an attosecond, depicted as an orange collection of hexagons, on the left, with the age of the universe, depicted as a dark vacuum on the right, and a heartbeat, depicted as a human heart, in the middle.
An attosecond is incredibly small when compared to a second. ©Johan Jarnestad/The Royal Swedish Academy of Sciences[6], CC BY-NC-ND[7]

Previously, scientists could study the motion of heavier and slower-moving atomic nuclei with femtosecond (10⁻¹⁵) light pulses[8]. One thousand attoseconds are in 1 femtosecond. But researchers couldn’t see movement on the electron scale until they could generate attosecond light pulses – electrons move too fast for scientists to parse exactly what they are up to at the femtosecond level.

Attosecond pulses

The rearrangement of electrons in atoms and molecules guides a lot of processes in physics, and it underlies practically every part of chemistry. Therefore, researchers have put a lot of effort into figuring out how electrons are moving and rearranging.

However, electrons move around very rapidly in physical and chemical processes, making them difficult to study. To investigate these processes, scientists use spectroscopy[9], a method of examining how matter absorbs or emits light. In order to follow the electrons in real time[10], researchers need a pulse of light that is shorter than the time it takes for electrons to rearrange.

Pump-probe spectroscopy is a common technique in physics and chemistry and can be performed with attosecond light pulses.

As an analogy, imagine a camera that could only take longer exposures, around 1 second long. Things in motion, like a person running toward the camera or a bird flying across the sky, would appear blurry in the photos taken, and it would be difficult to see exactly what was going on.

Then, imagine you use a camera with a 1 millisecond exposure. Now, motions that were previously smeared out would be nicely resolved into clear and precise snapshots. That’s how using the attosecond scale, rather than the femtosecond scale, can illuminate electron behavior.

Attosecond research

So what kind of research questions can attosecond pulses help answer?

For one, breaking a chemical bond is a fundamental process in nature where electrons that are shared between two atoms separate out into unbound atoms. The previously shared electrons undergo ultrafast changes during this process, and attosecond pulses[11] made it possible for researchers to follow the real-time breaking of a chemical bond.

The ability to generate attosecond pulses[12] – the research for which three researchers earned the 2023 Nobel Prize in physics[13] – first became possible in the early 2000s, and the field has continued to grow rapidly[14] since. By providing shorter snapshots of atoms and molecules, attosecond spectroscopy has helped researchers understand electron behavior in single molecules, such as how electron charge migrates[15] and how chemical bonds[16] between atoms break.

On a larger scale, attosecond technology has also been applied to studying how electrons behave in liquid water[17] as well as electron transfer in solid-state semiconductors[18]. As researchers continue to improve their ability to produce attosecond light pulses, they’ll gain a deeper understanding of the basic particles that make up matter.

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a smartphone screen displays an alert

The Wireless Emergency Alert system[1] is scheduled to have its third nationwide test[2] on Oct. 4, 2023. The Wireless Emergency Alert system is a public safety system that allows authorities to alert people via their mobile devices of dangerous weather, missing children and other situations requiring public attention.

Similar tests in 2018 and 2021 caused a degree of public confusion[3] and resistance[4]. In addition, there was confusion around the first test of the U.K. system in April 2023[5], and an outcry surrounding accidental alert messages such as those sent in Hawaii in January 2018[6] and in Florida in April 2023[7].

The federal government lists five types of emergency alerts[8]: National (formerly labeled Presidential), Imminent Threat, Public Safety, America’s Missing: Broadcast Emergency Response (Amber), and Opt-in Test Messages. You can opt out of any except National Alerts, which are reserved for national emergencies. The Oct. 4 test is a National Alert.

We are a media studies researcher[9] and a communications researcher[10] who study emergency alert systems. We believe that concerns about previous tests raise two questions: Is public trust in emergency alerting eroding? And how might the upcoming test rebuild it?

Confusion and resistance

In an ever-updating digital media environment, emergency alerts appear as part of a constant stream of updates, buzzes, reminders and notifications on people’s smartphones. Over-alerting is a common fear in emergency management circles[11] because it can lead people to ignore alerts and not take needed action. The sheer volume of different updates can be similarly overwhelming, burying emergency alerts in countless other messages. Many people have even opted out of alerts[12] when possible, rummaging through settings and toggling off every alert they can find.

Even when people receive alerts, however, there is potential for confusion and rejection. All forms of emergency alerts rely on the recipients’ trust[13] in the people or organization responsible for the alert. But it’s not always clear who the sender is. As one emergency manager explained to one of us regarding alerts used during COVID-19: “People were more confused because they got so many different notifications, especially when they don’t say who they’re from.”

When the origin of an alert is unclear, or the recipient perceives it to have a political bias counter to their own views[14], people may become confused or resistant to the message. Prior tests and use of the Wireless Emergency Alert system have indicated strong anti-authority attitudes, particularly following the much-derided 2018 test of what was then called the Presidential Alert message class[15]. There are already conspiracy theories[16] online about the upcoming test.

People receive mobile alerts from then-president Donald Trump in a ‘Saturday Night Live’ sketch aired on Oct. 6, 2018.

Trust in alerts is further reduced by the overall lack of testing and public awareness work done on behalf of the Wireless Emergency Alert system since its launch in June 2012[17]. As warning expert Dennis Mileti explained in his 2018 Federal Emergency Management Agency PrepTalk[18], routine public tests are essential for warning systems’ effectiveness. However, the Wireless Emergency Alert system has been tested at the national level only twice, and there has been little public outreach to explain the system by either the government or technology companies.

More exposure and info leads to more trust

The upcoming nationwide test may offer a moment that could rebuild trust in the system. A survey administered in the days immediately following the 2021 national test found that more respondents believed that the National Alert message class label would signal more trustworthy information[19] than the Presidential Alert message class label.

Similarly, in contrast to the 2021 test, which targeted only select users, the Oct. 4 test is slated to reach all compatible devices in the U.S. Since users cannot opt out of the National Alert message class, this week’s test is a powerful opportunity to build awareness about the potential benefits of a functional federal emergency alert system.

The Oct. 4 test message is expected to state, “THIS IS A TEST of the National Wireless Emergency Alert system. No action is needed.” We instead suggest that action is, in fact, urgently needed to help people better understand the rapidly changing mobile alert and warning ecosystem that confronts them. Familiarity with this system is what will allow it to support public health and safety, and address the crises of the 21st century.

Here are steps that you can take now to help make the Wireless Emergency Alert system more effective:

  • The Wireless Emergency Alert system is only one form of emergency alert. Identify which mobile notification systems are used by your local emergency management organizations: police, fire and emergency services. Know which systems are opt-in and opt-out, and opt in to those needed. Ensure access to other sources of information during an emergency, such as local radio and television, or National Oceanic and Atmospheric Administration weather radio.

  • Understand the meaning of mobile device notification settings. Just because you are opted in to “Emergency Alerts” on your cellphone does not necessarily mean you are signed up to receive notifications from local authorities. Check the FEMA website[20] for information about the Wireless Emergency Alert system and your local emergency management organizations’ websites about opt-in systems.

  • Have a plan for contacting family, friends and neighbors during an emergency. Decide in advance who will help the vulnerable members of your community.

  • Find out if your local emergency management organizations test their alert systems, and make sure to receive those local tests.

  • Anticipate the possibility that mobile systems will be damaged or unavailable during a crisis and prepare essentials for sheltering in place or quick evacuation.

Finally, push back on the lack of information and rise of misinformation about alerts by sharing reliable information about emergency alerts with your family and friends.

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