Date:
Source:
Health Data Science
Summary:
A global study of over 88,000 adults reveals that poor sleep habits—like going to bed inconsistently or having disrupted circadian rhythms—are tied to dramatically higher risks for dozens of diseases, including liver cirrhosis and gangrene. Contrary to common belief, sleeping more than 9 hours wasn't found to be harmful when measured objectively, exposing flaws in previous research. Scientists now say it's time to redefine “good sleep” to include regularity, not just duration, as biological mechanisms like inflammation may underlie these powerful sleep-disease links.

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Your Sleep Schedule Could Be Making You Sick
Poor sleep regularity—not just duration—is linked to disease risk in over 90 conditions, including liver and circulatory disorders, according to new objective data. Credit: Shutterstock

A groundbreaking international study, recently published in Health Data Science, analyzed objective sleep data from 88,461 adults in the UK Biobank and found significant associations between sleep traits and 172 diseases. The research, led by teams from Peking University and Army Medical University, highlights sleep regularity -- such as bedtime consistency and circadian rhythm stability -- as an underrecognized but critical factor in disease risk.

Using actigraphy data over an average of 6.8 years, researchers identified that 92 diseases had over 20% of their risk attributable to poor sleep behavior. Notably, irregular bedtime (after 00:30) was linked to a 2.57-fold higher risk of liver cirrhosis, while low interdaily stability increased the risk of gangrene by 2.61 times.

Importantly, the study challenges previous claims that "long sleep" (≥9 hours) is harmful. While subjective reports have linked long sleep to stroke and heart disease, objective data revealed this association in only one disease. Misclassification may be to blame: 21.67% of "long sleepers" actually slept less than 6 hours, suggesting that time spent in bed is often confused with actual sleep time.

"Our findings underscore the overlooked importance of sleep regularity," said Prof. Shengfeng Wang, senior author of the study. "It's time we broaden our definition of good sleep beyond just duration."

The team confirmed several associations in U.S. populations and identified inflammatory pathways as a possible biological link. Future research will explore causality and assess the impact of sleep interventions on chronic disease outcomes.


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Materials provided by Health Data Science. Note: Content may be edited for style and length.


Journal Reference:

  1. Yimeng Wang, Qiaorui Wen, Siwen Luo, Lijuan Tang, Siyan Zhan, Jia Cao, Shengfeng Wang, Qing Chen. Phenome-wide Analysis of Diseases in Relation to Objectively Measured Sleep Traits and Comparison with Subjective Sleep Traits in 88,461 Adults. Health Data Science, 2025; 5 DOI: 10.34133/hds.0161[1]

Cite This Page:

Health Data Science. "Your sleep schedule could be making you sick, says massive new study." ScienceDaily. ScienceDaily, 29 July 2025. <www.sciencedaily.com/releases/2025/07/250729001227.htm>.

Health Data Science. (2025, July 29). Your sleep schedule could be making you sick, says massive new study. ScienceDaily. Retrieved July 29, 2025 from www.sciencedaily.com/releases/2025/07/250729001227.htm

Health Data Science. "Your sleep schedule could be making you sick, says massive new study." ScienceDaily. www.sciencedaily.com/releases/2025/07/250729001227.htm (accessed July 29, 2025).

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Read more …Your sleep schedule could be making you sick, says massive new study

Regular walking is widely recognized for its significant benefits to overall health and well-being. Previous research has primarily focused on middle-to-high-income White populations. Now, a novel analysis using data from the Southern Community Cohort Study, involving 79,856 predominantly low-income and Black individuals across 12 southeastern US states, confirms the benefits of regular walking, especially at a faster pace, within a crucial, underrepresented group. The new study appearing in the American Journal of Preventive Medicine, published by Elsevier, underscores the importance of promoting walking, particularly at a brisk pace, as an effective form of physical activity for improving health.

Lead investigator Wei Zheng, MD, PhD, Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, School of Medicine, Vanderbilt University, and Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, says, "While the health benefits of daily walking are well-established, limited research has investigated effects of factors such as walking pace on mortality, particularly in low-income and Black/African-American populations. Our research has shown that fast walking as little as 15 minutes a day was associated with a nearly 20% reduction in total mortality, while a smaller reduction in mortality was found in association with more than three hours of daily slow walking. This benefit remained strong even after accounting for other lifestyle factors and was consistent across various sensitivity analyses."

Participants reported the average amount of time per day (minutes) they typically spend "walking slowly (such as moving around, walking at work, walking the dog, or engaging in light exercise)" and "walking fast (such as climbing stairs, brisk walking, or exercising)." Information regarding vital status and cause of death was obtained by linking the cohort to the National Death Index.

The protective effect of fast walking extended to all causes of death but was most pronounced for cardiovascular diseases. Importantly, the benefits of fast walking were independent of overall leisure-time physical activity levels (LTPA). Even for those who are already engaged in slow walking or some LTPA, adding more fast walking further reduced mortality.

According to the study the benefits of fast walking related to cardiovascular health are:

  • Boosts heart efficiency: As an aerobic exercise, fast walking improves cardiac output, increases oxygen delivery, and enhances the efficiency of the heart's pumping action, leading to better overall cardiovascular health.
  • Manages cardiovascular risk factors: Regular fast walking helps control body weight and composition, reducing obesity and related risks like hypertension and dyslipidemia.
  • Highly accessible: Fast walking is a convenient, low-impact activity suitable for individuals of all ages and fitness levels.

Low-income populations often face economic constraints and are more likely to reside in impoverished, highly polluted communities with limited access to safe walking spaces. Additionally, these populations tend to have a higher prevalence of lifestyle behaviors that may increase disease risk and mortality, such as lower quality diet, cigarette smoking, and heavy alcohol consumption. At the same time, there are other challenges for individuals with low income such as lack of access to health insurance or healthcare that may also increase mortality. These factors collectively contribute to an increased mortality among low-income individuals and may potentially elucidate the racial disparities observed in longevity. By demonstrating the benefits of fast walking in this study, this research provides direct evidence to inform targeted interventions and policies to improve health equity.

Lead author of the article Lili Liu, MPH, Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, School of Medicine, and Vanderbilt University, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, concludes, "Public health campaigns and community-based programs can emphasize the importance and availability of fast walking to improve health outcomes, providing resources and support to facilitate increased fast walking within all communities. Furthermore, the findings of the reduced mortality associated with fast walking pace were supported by previous studies conducted in middle- and upper-middle-income populations. Individuals should strive to incorporate more intense physical activity into their routines, such as brisk walking or other forms of aerobic exercise."

Read more …Walk faster, live longer: How just 15 minutes a day can boost lifespan

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