Researchers have identified new variations in neuroblastoma that could lead to a more accurate prognosis and better-targeted treatments for this devastating childhood cancer. A study reveals three new subgroups of the most common type of neuroblastoma, each with different genetic traits, expected outcomes, and distinguishing features that offer clues as to which treatments may be most effective.
Read more: Research could unlock more precise prognoses and targeted treatments for children with cancer
Researchers use network analysis to study whether it can reveal the subtle changes associated with subjective cognitive decline that cannot otherwise be detected through standard test analyses. By running a statistical analysis of data merged from two large Canadian data sets, the researchers were able to visualize the strength of relationships between the nodes among people who are classified as cognitively normal (CN), or who have diagnoses of subjective cognitive decline (SCD), mild cognitive impairment (MCI) or Alzheimer's disease (AD).
Read more: Cognitive decline may be detected using network analysis, according to Concordia researchers
Esophageal squamous cell carcinoma (ESCC) accounts for around 90% of esophageal cancers, especially in East Asia. New findings in indicate that periostin, or POSTN, promotes ESCC progression by enhancing cancer and stromal cell migration in cancer-associated fibroblasts (CAFs). Therefore, it may be a novel therapeutic target for treating ESCC.
Read more: Periostin shows promise to help fight a common form of esophageal cancer