From low-carb ice cream to keto protein bars to "sugar-free" soda, the decades-old sweetener erythritol is everywhere.
But new University of Colorado Boulder research shows the popular sugar substitute and specialty food additive comes with serious downsides, impacting brain cells in numerous ways that can boost risk of stroke.
The study was published in the Journal of Applied Physiology.
"Our study adds to the evidence suggesting that non-nutritive sweeteners that have generally been purported to be safe, may not come without negative health consequences," said senior author Christopher DeSouza, professor of integrative physiology and director of the Integrative Vascular Biology Lab.
First approved by the Food and Drug Administration in 2001, erythritol is a sugar alcohol, often produced by fermenting corn and found in hundreds of products. It has almost no calories, is about 80% as sweet as table sugar, and has negligible impact on insulin levels, making it a favorite for people trying to lose weight, keep their blood sugar in check or avoid carbohydrates.
But recent research has begun to shed light on its risks.
One recent study involving 4,000 people in the U.S. and Europe found that men and women with higher circulating levels of erythritol were significantly more likely to have a heart attack or stroke within the next three years.
DeSouza and first author Auburn Berry, a graduate student in his lab, set out to understand what might be driving that increased risk.
Researchers in the lab treated human cells that line blood vessels in the brain for three hours with about the same amount of erythritol contained in a typical sugar-free beverage.
They observed that the treated cells were altered in numerous ways: They expressed significantly less nitric oxide, a molecule that relaxes and widens blood vessels, and more endothelin-1, a protein that constricts blood vessels. Meanwhile, when challenged with a clot-forming compound called thrombin, cellular production of the natural clot-busting compound t-PA was "markedly blunted." The erythritol-treated cells also produced more reactive oxygen species (ROS), a.k.a. "free radicals," metabolic byproducts which can age and damage cells and inflame tissue.
"Big picture, if your vessels are more constricted and your ability to break down blood clots is lowered, your risk of stroke goes up," said Berry. "Our research demonstrates not only that, but how erythritol has the potential to increase stroke risk."
DeSouza notes that their study used only a serving-size worth of the sugar substitute. For those who consume multiple servings per day, the impact, presumably, could be worse.
The authors caution that their study was a laboratory study, conducted on cells, and larger studies in people are needed.
That said, De Souza encourages consumers to read labels, looking for erythritol or "sugar alcohol" on the label.
"Given the epidemiological study that inspired our work, and now our cellular findings, we believe it would be prudent for people to monitor their consumption of non-nutrient-sweeteners such as this one," he said.
Romaine lettuce has a long history of E. coli outbreaks, but scientists are zeroing in on why. A new study reveals that the way lettuce is irrigated—and how it’s kept cool afterward—can make all the difference. Spraying leaves with untreated surface water is a major risk factor, while switching to drip or furrow irrigation cuts contamination dramatically. Add in better cold storage from harvest to delivery, and the odds of an outbreak plummet. The research offers a clear, science-backed path to safer salads—one that combines smarter farming with better logistics.
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Scientists have traced major E. coli risks in romaine to how it’s watered and cooled. Changing irrigation methods and improving cold storage could dramatically reduce contamination. Credit: Shutterstock
E. coli outbreaks in romaine lettuce have long been a public health concern. and now a new Cornell University paper suggests that a combination of efforts in the field, and even postharvest techniques, can minimize risk to human health.
Co-authored by Renata Ivanek, a professor in the department of population medicine and diagnostic sciences, and Martin Wiedmann, professor in food safety, the paper outlines interventions likely to make a concrete difference in the safety of the nation's romaine.
"This study supports that interventions should focus on reducing produce contamination via contaminated irrigation water, on assuring that produce washes applied during processing consistently deliver reasonably high reductions of bacterial numbers, and on improving temperature control during distribution," Wiedmann said.
"We tried to describe the system as holistically as possible to account for different risk factors and how they could have interactions," Ivanek said. "There's not just one intervention that will save us all. We spent a lot of time trying to understand the preharvest component, especially the irrigation water piece and how much risk can be explained by that."
Study results suggested that much contamination originates from irrigation with untreated surface water applied through overhead spray irrigation systems. They found that risk from irrigation was reduced either through water treatments or by switching to furrow or drip irrigation.
"While not the most common system, spray irrigation is used in a number of fields for its benefits during germination, its cooling effect on plants and other reasons. But drip or furrow irrigation reduces the probability that water directly touches the leaves," Ivanek said, acknowledging that switching to these other irrigation systems introduces significant potential additional costs to grower.
Ivanek and her co-authors also explored the importance of maintaining proper cold storage temperatures along the entire supply chain to romaine's final destination.
"Time and temperature play a role in food safety, and also in food quality and shelf life," she said, describing a "perfect storm" if contamination happens at the farm or processing level and then improper transportation temperatures allow bacteria to grow.
The comprehensive practices and interventions explored in this study intend to aid decision-makers in establishing and enhancing food safety best management practices, Ivanek said.
"The big message is the American food supply chain is extremely safe compared to other countries," she said. "We're exploring how can we make it even safer and where we should put additional effort."
Story Source:
Materials provided by Cornell University. Note: Content may be edited for style and length.
Journal Reference:
Ece Bulut, Sarah I. Murphy, Laura K. Strawn, Michelle D. Danyluk, Martin Wiedmann, Renata Ivanek. Risk assessment of Escherichia coli O157:H7 along the farm-to-fork fresh-cut romaine lettuce supply chain. Scientific Reports, 2025; 15 (1) DOI: 10.1038/s41598-025-01585-z[1]
Cite This Page:
Cornell University. "Dirty water, warm trucks, and the real reason romaine keeps making us sick." ScienceDaily. ScienceDaily, 19 July 2025. <www.sciencedaily.com/releases/2025/07/250718031225.htm>.
Cornell University. (2025, July 19). Dirty water, warm trucks, and the real reason romaine keeps making us sick. ScienceDaily. Retrieved July 19, 2025 from www.sciencedaily.com/releases/2025/07/250718031225.htm
Cornell University. "Dirty water, warm trucks, and the real reason romaine keeps making us sick." ScienceDaily. www.sciencedaily.com/releases/2025/07/250718031225.htm (accessed July 19, 2025).
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A new treatment that uses music therapy on dementia wards could improve care and support for some of the NHS's most vulnerable patients.
Researchers at Anglia Ruskin University (ARU) and Cambridgeshire and Peterborough NHS Foundation Trust have piloted a music therapy approach called MELODIC, across two NHS dementia wards.
More alternatives to psychotropic medication are needed to support dementia patients who experience severe distress.
The pilot study involved a music therapist being embedded on hospital wards, the delivery of clinical music sessions and the implementation of musical care plans for each patient, and results from the research have now been published in the journal Frontiers in Psychiatry.
Music therapy, delivered by trained therapists, can include singing, playing or listening to music. The therapist can also identify specific ways that music can be used by families and carers in an individual's daily care routine.
During the study, patient data suggested a slight improvement in quality-of-life scores among patients and a reduction in the severity of distress symptoms and disruptiveness, although agitation scores increased slightly.
There were no increases in routinely reported incidents, and no adverse events related to music therapy interventions were reported. This is relevant for future research on mental health dementia wards where limited studies have been conducted to date.
Lead author Naomi Thompson, a researcher at the Cambridge Institute for Music Therapy Research at Anglia Ruskin University (ARU), said: "People with dementia on inpatient mental health wards are often experiencing very high levels of distress, and staff are under immense pressure to manage this in ways that are safe and compassionate.
"Our study yielded promising results and importantly showed that the MELODIC tool can be used effectively in these highly complex settings, giving an alternative option to current ways of managing severe distress, such as psychotropic medication."
The approach was shaped by interviews with 49 healthcare professionals, patients, and their families about their experiences managing distress on dementia wards and using music in everyday care and life to help develop the intervention, with findings published in the Journal of Geriatric Psychiatry.
Importantly, the intervention -- which has been co-designed by clinicians, researchers, and people with lived experience - cost just £2,025 per month for the therapist and £400 initial outlay for equipment, suggesting a low-cost, scalable model.
Dr Ben Underwood, Research and Development Director and Honorary Consultant Psychiatrist at CPFT said: "Some people with dementia can get so confused and distressed that we need to admit them to hospital to keep them safe. It can be difficult to manage distress in a ward environment and hard for patients, families and staff.
"I am very excited that it may now be possible for NHS staff to improve their experience on dementia wards using the power of music, and we look forward to working with ARU to develop this further."
The current study was funded by the National Institute for Health and Care Research (NIHR), and is published in the journal Frontiers in Psychiatry.
