Dementias such as Alzheimer's disease are estimated to affect more than 57.4 million people worldwide, a number that is expected to almost triple to 152.8 million cases by 2050. The impacts on the individuals, families and caregivers and society at large are immense.

While there are some indications that the prevalence of dementia is decreasing in Europe and North America, suggesting that it may be possible to reduce the risk of the disease at a population level, elsewhere the picture is less promising.

Air pollution has recently been identified as a risk factor for dementia, with several studies pointing the finger at a number of pollutants. However, the strength of evidence and ability to determine a causal effect has been varied.

In a paper published on July 24 in The Lancet Planetary Health, a team led by researchers at the Medical Research Council (MRC) Epidemiology Unit, University of Cambridge, carried out a systematic review and meta-analysis of existing scientific literature to examine this link further. This approach allowed them to bring together studies that on their own may not provide sufficient evidence, and which sometimes disagree with each other, to provide more robust overarching conclusions.

In total, the researchers included 51 studies, including data from more than 29 million participants, mostly from high-income countries. Of these, 34 papers were included in the meta-analysis: 15 originated in North America, 10 in Europe, seven in Asia, and two in Australia.

The researchers found a positive and statistically-significant association between three types of air pollutant and dementia. These were:

• Particulate matter with a diameter of 2.5 microns or less (PM_2.5), a pollutant made up of tiny particles small enough that they can be inhaled deep into the lungs. These particles come from several sources, including vehicle emissions, power plants, industrial processes, wood burning stoves and fireplaces, and construction dust. They also form in the atmosphere because of complex chemical reactions involving other pollutants such as sulphur dioxide and nitrogen oxides. The particles can stay in the air for a long time and travel a long way from where they were produced.

• Nitrogen dioxide (NO₂), one of the key pollutants that arise from burning fossil fuels. It is found in vehicle exhaust, especially diesel exhaust, and industrial emissions, as well as those from gas stoves and heaters. Exposure to high concentrations of nitrogen dioxide can irritate the respiratory system, worsening and inducing conditions like asthma and reducing lung function.
• Soot, from sources such as vehicle exhaust emissions and burning wood. It can trap heat and affect the climate. When inhaled, it can penetrate deep into the lungs, aggravating respiratory diseases and increasing the risk of heart problems.

According to the researchers, for every 10 micrograms per cubic meter (μg/m³) of PM_2.5, an individual's relative risk of dementia would increase by 17%. The average roadside measurement for PM_2.5 in Central London in 2023 was 10 μg/m³.

For every 10 μg/m³ of NO₂, the relative risk increased by 3%. The average roadside measurement for NO₂ in Central London in 2023 was 33 µg/m³.

For each 1 μg/m³ of soot as found in PM_2.5, the relative risk increased by 13%. Across the UK, annual mean soot concentrations measured at select roadside locations in 2023 were 0.93 μg/m³ in London, 1.51 μg/m³ in Birmingham and 0.65 μg/m³ Glasgow.

Senior author Dr Haneen Khreis from the MRC Epidemiology Unit said: "Epidemiological evidence plays a crucial role in allowing us to determine whether or not air pollution increases the risk of dementia and by how much. Our work provides further evidence to support the observation that long-term exposure to outdoor air pollution is a risk factor for the onset of dementia in previously healthy adults.

"Tackling air pollution can deliver long-term health, social, climate, and economic benefits. It can reduce the immense burden on patients, families, and caregivers, while easing pressure on overstretched healthcare systems."

Several mechanisms have been proposed to explain how air pollution may cause dementia, primarily involving inflammation in the brain and oxidative stress (a chemical process in the body that can cause damage to cells, proteins, and DNA). Both oxidative stress and inflammation play a well-established role in the onset and progression of dementia. Air pollution is thought to trigger these processes through direct entry to the brain or via the same mechanisms underlying lung and cardiovascular diseases. Air pollution can also enter circulation from the lungs and travel to solid organs, initiating local and wide-spread inflammation.

The researchers point out that the majority of people included in the published studies were white and living in high-income countries, even though marginalised groups tend to have a higher exposure to air pollution. Given that studies have suggested that reducing air pollution exposure appears to be more beneficial at reducing the risk of early death for marginalised groups, they call for future work to urgently ensure better and more adequate representation across ethnicities and low- and middle-income countries and communities.

Joint first author Clare Rogowski, also from the MRC Epidemiology Unit, said: "Efforts to reduce exposure to these key pollutants are likely to help reduce the burden of dementia on society. Stricter limits for several pollutants are likely to be necessary targeting major contributors such as the transport and industry sectors. Given the extent of air pollution, there is an urgent need for regional, national, and international policy interventions to combat air pollution equitably."

Further analysis revealed that while exposure to these pollutants increased the risk of Alzheimer's disease, the effect seemed stronger for vascular dementia, a type of dementia caused by reduced blood flow to the brain. Around 180,000 people in the UK are thought to be affected by this type of dementia. However, as there were only a small number of studies that examined this difference, the researchers did not class it as statistically significant.

Joint first author Dr Christiaan Bredell from the University of Cambridge and North West Anglia NHS Foundation Trust said: "These findings underscore the need for an interdisciplinary approach to dementia prevention. Preventing dementia is not just the responsibility of healthcare: this study strengthens the case that urban planning, transport policy, and environmental regulation all have a significant role to play."

The research was funded by the European Research Council under the Horizon 2020 research and innovation program and from the European Union's Horizon Europe Framework Programme.

il 7000 steps, at which point the benefits began to taper off

A major new study led by the University of Sydney suggests that walking 7000 steps a day offers similar health benefits across several outcomes as walking 10,000.

Led by Professor Melody Ding from the School of Public Health, the study was published in The Lancet Public Healthand analysed data from 57 studies from 2014 to 2025 that were conducted in more than ten countries including Australia, USA, UK and Japan.

The largest and most comprehensive review to date, the researchers examined the impact that different daily step counts have on the chance of dying from cardiovascular disease and cancer, and developing diseases such as cancer, type 2 diabetes, dementia and depression. Professor Melody Ding says the findings offer a more achievable benchmark for people who struggle to meet traditional exercise guidelines.

"Aiming for 7000 steps is a realistic goal based on our findings, which assessed health outcomes in a range of areas that hadn't been looked at before," said Professor Ding.

"However, for those who cannot yet achieve 7000 steps a day, even small increases in step counts, such as increasing from 2000 to 4000 steps a day, are associated with significant health gain.

"We know daily step count is linked to living longer, but we now also have evidence that walking at least 7000 steps a day can significantly improve eight major health outcomes -- including reducing risk of cardiovascular disease, dementia and depressive symptoms."

Health benefits at different step counts

The researchers looked at studies in which participants wore step counting devices, such as pedometers, accelerometers and fitness trackers, to track their daily step counts. Starting at 2000 steps, experts compared the health outcomes of people walking more steps a day at 1000 step increments to see whether there was any difference in the risk of early death or other major diseases.

When compared with 2000 steps a day, researchers found that:

• Walking 7000 steps a day reduced the risk of death by 47 percent, which was almost identical to the benefit seen at walking 10,000 steps per day.
• Dementia risk dropped by 38 percent from walking 7000 steps a day, with only a 7 percent extra reduction at 10,000 steps.
• Risk of type 2 diabetes fell by 22 percent from walking 10,000 steps a day and reduced to 27 percent at 12,000 steps.
• Significant health improvements were seen when people increased their average daily steps from 2000 to between 5000 and 7000 steps.

"For people who are already active, 10,000 steps a day is great," said Dr Katherine Owen, co-author and chief analyst of the study from the School of Public Health. "But beyond 7000 steps, the extra benefits for most of the health outcomes we looked at were modest."

The researchers are working with the Australian government to use the evidence from this study to inform future updates to physical activity guidelines.

"Our research helps to shift the focus from perfection to progress. Even small increases in daily movement can lead to meaningful health improvements," said Professor Ding.

Experts are calling for future studies to explore how step goals should vary based on age, health status and region, and to include diverse populations and longer-term data to strengthen the evidence. Professor Ding says this kind of detail is rare and will be useful for health practitioners when tailoring advice for patients.