Researchers have identified that a transient inflammatory pain causes mitochondrial and redox changes in sensory neurons that persist beyond pain resolution. These changes appear to predispose to a failure in resolution of pain caused by a subsequent inflammation. Additionally, targeting the cellular redox balance prevents and treats chronic inflammatory pain in rodents.
Read more …Disturbances in sensory neurons may alter transient pain into chronic pain
Scientists have discovered how mitochondria sense and control their glutathione levels, an antioxidant produced throughout the body. The first nutrient-sensing mechanism identified for an organelle, the finding has great translational potential.
Read more …How the antioxidant glutathione keeps mitochondria healthy