In dementia diseases such as Alzheimer's, incorrectly folded proteins accumulate in the brain. Researchers have now resolved a particularly active species of protein fibrils with unprecedented precision. The formation of potentially toxic molecules on the surface of protein fibrils was studied from early to late stages spanning over a period of hours.
Read more …Superspreader fibrils caught in the act
The human genetic code is fully mapped out, providing scientists with a blueprint of the DNA to identify genomic regions and their variations responsible for diseases. Traditional statistical tools effectively pinpoint these genetic 'needles in the haystack,' yet they face challenges in understanding how many genes contribute to diseases, as seen in diabetes or schizophrenia.
Read more …Understanding how mutations affect diseases