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Tuesday, September 16, 2025

New combination immunotherapy for melanoma and breast cancer

A research team has investigated a new combination therapy against cancer. This therapy employs systemic administration of the tissue hormone interferon-I combined with local application of Imiquimod. This combination showed promising results in topically accessible tumors like melanoma and breast cancer models: The therapy led to the death of tumor cells at the treated sites and simultaneously activated the adaptive immune system to fight even distant metastases. The results could improve the treatment of superficial tumors such as melanoma and breast cancer.

Uncovering the role of Y chromosome genes in male fertility in mice

Researchers have uncovered which genes on the Y chromosome regulate the development of sperm and impact fertility in male mice. This research could help us understand why some men don't produce enough sperm and are infertile.

Health and Human Services secretary influences every aspect of America’s health

The secretary of the Department of Health and Human Services, or HHS, plays a significant role in every American’s access to health care and in the nation’s overall well-being.

Under the secretary’s leadership, the multiple agencies that constitute HHS oversee the financing of Medicare and Medicaid, conduct research to improve care quality, monitor health care fraud and abuse, and respond to pandemics.

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Artificial intelligence in biomedicine: A key to analyzing millions of individual cells

Our bodies are made up of around 75 billion cells. But what function does each individual cell perform and how greatly do a healthy person's cells differ from those of someone with a disease? To draw conclusions, enormous quantities of data must be analyzed and interpreted. For this purpose, machine learning methods are applied. Researchers have now tested self-supervised learning as a promising approach for testing 20 million cells or more.

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