Faulty DNA disposal system causes inflammation

Scientists discovered a pathway from mitochondrial DNA replication stress to immune system activation and inflammation, finding that endosomes responsible for disposing of dysfunctional mitochondrial DNA were leaking mitochondrial DNA into the cell and prompting the inflammatory immune response. The pathway provides new targets for therapeutics that disrupt inflammation during aging and disease.

Scientists discovered a pathway from mitochondrial DNA replication stress to immune system activation and inflammation, finding that endosomes responsible for disposing of dysfunctional mitochondrial DNA were leaking mitochondrial DNA into the cell and prompting the inflammatory immune response. The pathway provides new targets for therapeutics that disrupt inflammation during aging and disease.

Read more https://www.sciencedaily.com/releases/2024/02/240208121733.htm