Researchers reveal that metabolic enzymes known for their roles in energy production and nucleotide synthesis are taking on unexpected 'second jobs' within the nucleus, orchestrating critical functions like cell division and DNA repair. The discovery not only challenges longstanding biological paradigms in cellular biology but also opens new avenues for cancer therapies, particularly against aggressive tumours like triple-negative breast cancer (TNBC).
Read more …'Moonlighting' enzymes can lead to new cancer therapies

A young woman looks at her dentist who is using instruments to probe her teeth.

For more than 50 million Americans, finding a dentist is a difficult[1] – in some cases, impossible[2] – proposition. Many rural communities don’t have a dentist[3]. People of color and those with disabilities often lack access[4], and only about one-third of dentists accept Medicaid[5].

That’s why dental therapists – professionals who don’t have a full dentistry degree but are trained to provide basic dental care...

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