Tuesday, May 13, 2025
Tuesday, May 13, 2025

Aptamers, nucleic acids capable of selectively binding to viruses, proteins, ions, small molecules, and various other targets, are garnering attention in drug development as potential antibody substitutes for their thermal and chemical stability as well as ability to inhibit specific enzymes or target proteins through three-dimensional binding. They also hold promise for swift diagnoses of colon cancer and other challenging diseases by targeting elusive biomarkers. Despite their utility, these aptamers are susceptible to easy degradation by multiple enzymes, presenting a significant challenge.
Read more …Aptamers: lifesavers; ion shields: aptamer guardians

Just like a doctor adjusts the dose of a medication to the patient's needs, the expression of therapeutic genes, those modified in a person to treat or cure a disease via gene therapy, also needs to be maintained within a therapeutic window. Staying within the therapeutic window is important as too much of the protein could be toxic, and too little could result in a small or no therapeutic effect. Researchers now report on a technology to effectively regulate gene expression, a promising solution to fill this gap in gene therapy clinical applications.
Read more …A novel switch to turn genes on/off on cue, a promising step toward safer gene therapy

More Articles …

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  4. Revolutionary nanodrones enable targeted cancer treatment
  5. One dead following cheese recall over E. coli
  6. Care home left patient lying in urine-soaked sheets
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