An innovative synthesis strategy opened up the way to 2D/3D fused frameworks using inexpensive quinolines as feedstock, report scientists. By leveraging a light-sensitive borate intermediate, the scientists could transform quinoline derivatives into a great variety of 2D/3D fused frameworks in a straightforward and cost-effective manner. Their findings are expected to enable the synthesis of highly customizable drug candidates.
Read more: Transforming inexpensive quinolines into complex drug candidates
When low doses of cancer drugs are administered continuously near malignant brain tumors using so-called iontronic technology, cancer cell growth drastically decreases. Researchers demonstrated this in experiments with bird embryos. The results are one step closer to new types of effective treatments for severe cancer forms.
Read more: More effective cancer treatment with iontronic pump
Tuberculosis is a serious health threat, and the efficacy of the BCG vaccine against tuberculosis diminishes in adulthood, making booster vaccines a realistic option. Mycobacterial DNA-binding protein 1 (MDP1), a protein found in Mycobacterium tuberculosis, elicits higher protective IFN-gamma responses in individuals who suppress tuberculosis, thus making it a vaccine candidate.
Read more: A new tuberculosis vaccine candidate recombinant protein with additional post-translational...
Autoimmune diseases cannot currently be cured, only treated, and this is also true for neuromyelitis optica spectrum disorder, which affects the central nervous system. A study of how the treatment acts on the immune system shows that it shifts the balance of types of immune cells. This finding may represent a step toward the development of personalized medicine for autoimmune diseases.
Read more: Treatment for autoimmune disorder acts on balance of immune cell types