Researchers have uncovered the mechanisms that protect the genome from the metabolic toxin formaldehyde in AMeD, a rare congenital disorder of premature aging and myeloid leukemia development. The team used human cells and a new animal model to recapitulate AMeD symptoms and their findings open the door to new therapeutic interventions.
Read more …How do cells deal with Formaldehyde toxicity during growth and aging?
Researchers have found that being a carrier for sickle cell disease, known as having sickle cell trait, increases the risk of blood clots, a risk that is the same among diverse human populations that may not traditionally be associated with sickle cell disease. The study provides estimated clinical risks for people with sickle cell trait, which can inform clinical practice guidelines. Researchers examined the largest and most diverse set of people with sickle cell trait to date, which includes data from over 19,000 people of various ancestral backgrounds with sickle cell trait.
Read more …Genetic carriers for sickle cell disease have higher risks of blood clots across diverse ancestries