Researchers describe how specific gene activity could potentially enhance immune cell production. The researchers wanted to understand the mechanism of why some hematopoietic stem cells produce more immune cells, while other stem cells produce fewer. The research team pioneered new techniques for understanding the quantitative association between immune cell production and gene expression in lab mice. The scientists labeled individual stem cells with genetic 'barcodes' to track their immune cell production. They then correlated the barcode tracking with measurements of gene expression activity. They also developed innovative bioinformatics approaches to characterize their quantitative association. The scientists identified nearly 40 genes that are related to immune cell production. They discovered associations between the activity of these genes and both the quantity and variety of immune cells produced.
Read more …How gene activity modulates the amount of immune cell production in mice
Researchers have uncovered a distinctive network of lymphatic vessels at the back of the nose that plays a critical role in draining cerebrospinal fluid (CSF) from the brain. The study, sheds light on a previously unknown route for CSF outflow, potentially unlocking new avenues for understanding and treating neurodegenerative conditions.
Read more …Brain drain: Nasopharyngeal lymphatics found to be crucial for cerebrospinal fluid outflow
Researchers suggest giving people a script to get an honest answer -- even if it's a hard 'no' -- instead of acquiescence motivated by awkwardness or guilt.
Read more …How to elicit an authentic 'yes'