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Saturday, April 19, 2025

Delicate balancing act determines how many genome gateways form in cells

As warehouses go, nuclei are more like libraries than bank vaults. Too many cellular components need access to the genome to lock it down like Fort Knox. Instead, large groupings of more than 1,000 individual protein molecules called nuclear pore complexes (NPCs) pepper the dividing membrane, serving as gateways for materials and messages entering and exiting the nucleus. While the basic need for this shuttle service is constant, scientists have shown that cells dynamically adjust their amounts of NPCs like a retail store opening more or fewer checkout lines throughout the day. Scientists now reveal the results of screening the entire human genome to find factors influencing how many NPCs are assembled.

Change in oxygen standards for trauma patients?

A recent study finds most critically injured patients can recover with less supplemental oxygen than has previously been suggested.

New study links lower proportions of certain sleep stages to brain changes associated with Alzheimer's disease

New research reveals that lower proportions of specific sleep stages are associated with reduced brain volume in regions vulnerable to the development of Alzheimer's disease over time.

Doctor shortages have hobbled health care for decades − and the trend could be worsening

Americans are increasingly waiting weeks or even months to get an appointment to see a health care specialist ^[1].

This delay comes at a time when the population of aging adults is rising dramatically. By 2050, the number of adults over 85 is expected to triple ^[2], which will intensify the strain on an already stretched health care system. We wrote about this worsening challenge and its implications for the health care...

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