Some patients have experienced incredible recoveries after CAR-T-cell therapy. But they've also endured incredibly strong and scary side effects, in part because of the lymphodepleting chemotherapy that is performed before the CAR-T-cells are reinfused. What if CAR-T-cell therapy could be performed without lymphodepleting chemotherapy?
Read more: CAR-T-cell therapy without side effects? Researchers show results in preclinical models
Researchers have identified the structure of a special transporter found in red blood cells and how it interacts with drugs. Details on the findings could lead to the development of more targeted medicines. The research team found that this transporter facilitates the movement of a substance called bicarbonate, which certain drugs can inhibit. They discovered how these drugs block the transporter and devised novel compounds capable of achieving the same effect.
Read more: Scientists unlock secrets of red blood cell transporter, potentially paving the way for new drugs