Metabolic dysfunction-associated steatohepatitis (MASH) is a polygenic disorder influenced by multiple genes, but their specific roles in the progression of disease remain unknown. To address this gap, researchers conducted a series of experiments that identified the NACHT and WD repeat domain-containing protein 1 (Nwd1) gene and its role in liver pathogenesis. This breakthrough represents an important step toward establishing new therapeutic targets for MASH.
Read more …Nwd1 gene deletion triggers MASH-like pathology in mice