A study suggests that people with diets high in seafood may face a greater risk of exposure to PFAS -- the family of human-made toxins known as 'forever chemicals' -- than previously thought. The researchers stress the need for more stringent public health guidelines that establish how much seafood people can safely consume to limit their exposure, particularly in coastal areas where seafood is frequently eaten.
Read more …PFAS exposure from high seafood diets may be underestimated

A study has disentangled the mechanisms behind one of the ways melanoma cancer cells develop resistance to treatment. The study found that, in response to some drugs, melanomas can 'break' parts of their BRAF gene, which is mutated in 1 in 2 melanomas. This helps the tumor create alternative versions of the protein which lack regions targeted by one BRAF inhibitors, one of the main drugs used to treat this type of cancer, making treatment less effective. The findings pave the way for alternative strategies to treat BRAF-mutated melanoma, which leads to relapse in 50% of patients within a one-year period.
Read more …Melanomas resist drugs by 'breaking' genes

The Philadelphia Medical Examiner’s Office found that nitazenes, a synthetic opioid up to 40 times more powerful than fentanyl[1], were connected to at least five overdose deaths[2] in Philadelphia in the past two years.

The nitazene deaths are just a small

Read more …Nitazenes found in 5 overdose deaths in Philly – here’s what they are and why they’re so deadly

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