Tuberculosis is a serious health threat, and the efficacy of the BCG vaccine against tuberculosis diminishes in adulthood, making booster vaccines a realistic option. Mycobacterial DNA-binding protein 1 (MDP1), a protein found in Mycobacterium tuberculosis, elicits higher protective IFN-gamma responses in individuals who suppress tuberculosis, thus making it a vaccine candidate.
Read more …A new tuberculosis vaccine candidate recombinant protein with additional post-translational...

Autoimmune diseases cannot currently be cured, only treated, and this is also true for neuromyelitis optica spectrum disorder, which affects the central nervous system. A study of how the treatment acts on the immune system shows that it shifts the balance of types of immune cells. This finding may represent a step toward the development of personalized medicine for autoimmune diseases.
Read more …Treatment for autoimmune disorder acts on balance of immune cell types

Scientists have achieved a significant research milestone in the field of spinal cord injuries -- mapping out the cellular and molecular dynamics of paralysis in unprecedented detail with their open-source project 'Tabulae Paralytica'. Gr goire Courtine and his team have integrated cutting-edge cell and molecular mapping technologies with artificial intelligence to chart the complex molecular processes that unfold in each cell after spinal cord injuries (SCI). This seminal work not only identifies a specific set of neurons and genes that plays a key role for recovery but also proposes a successful gene therapy derived from its discoveries.
Read more …Tabulae Paralytica: Mapping the biology of spinal cord injury in unprecedented detail

Despite an ongoing outbreak of bird flu in dairy cows, the popularity of raw milk[1] has only risen. Advocates claim raw milk has superior health benefits over pasteurized milk. There is little evidence to support these claims, however, and the risk of serious illness is much greater.

Mississippi State University food scientists Juan Silva[2] and Joel Komakech[3] and nutritionist Mandy Conrad[4] explain the difference between...

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