Fever temperatures rev up immune cell metabolism, proliferation and activity, but they also -- in a particular subset of T cells -- cause mitochondrial stress, DNA damage and cell death, researchers have discovered. The findings offer a mechanistic understanding for how cells respond to heat and could explain how chronic inflammation contributes to the development of cancer.
Read more …Fever drives enhanced activity, mitochondrial damage in immune cells
Researchers investigated differences in T-cell responses between male and female patients with lung cancer that may help direct future treatments. T-cell responses are part of the adaptive immune system, which is part of the body's 'smart system' that monitors for threats and fights them with customized defenses.
Read more …Researchers identify sex-based differences in immune responses against tumors