In a study that spans more than a decade, researchers have looked at generations of families in a specific population to reveal the role newly inherited DNA variants play on recessive disease traits, and in the process, they have created a population specific database revealing unique DNA information unseen in larger cohorts.
Read more …The genomic architecture of inherited DNA variants
The bitter taste of certain drugs is a barrier to taking some medications as prescribed, especially for people who are particularly sensitive to bitter taste. A team found that the diabetes drug rosiglitazone could partially block the bitter taste of some especially bad-tasting medications. The hope is that repurposed drugs could be added in small doses to other medicines to make them less bitter and taste better, thereby encouraging compliance with bitter drug regimens.
Read more …Beating back bitter taste in medicine
A clinical trial showed that a nasal spray that patients administer at home, without a physician, successfully and safely treated recurrent episodes of a condition that causes rapid abnormal heart rhythms. The study provides real-world evidence that a wide range of patients can safely and effectively use the experimental drug, called etripamil, to treat recurrent paroxysmal supraventricular tachycardia (PSVT) episodes at home, potentially sparing them the need for repeated hospital trips for more invasive treatments.
Read more …Nasal spray safely treats recurrent abnormal heart rhythms, clinical trial suggests