Resting brain stem cells hardly differ from normal astrocytes, which support the nerve cells in the brain. How can almost identical cells perform such different functions? The key lies in the methylation of their genetic material, which endowes these special astrocytes with stem cell properties. In mice, the researchers showed that experimentally induced lack of blood supply in the brain epigenetically reprograms astrocytes into brain stem cells, which in turn can give rise to nerve progenitor cells. This discovery shows that astrocytes could potentially be used in regenerative medicine to replace damaged nerve cells.
Read more …Epigenetic changes reprogram astrocytes into brain stem cells

Fall brings football season in the U.S. and, with it, the parade of distinctively decorated helmets that the players wear[1].

Over time, the shape and size of these helmets have gradually changed, from the leather head coverings[2] of the early 20th century to the space-age plastic domes[3] we’re accustomed to seeing today.

But the visual profiles of some NFL football helmets may change drastically in 2024. The league has...

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The Centers for Disease Control and Prevention first used the term “AIDS[1]” on Sept. 24, 1982, more than a year after the first cases appeared in medical records. Those early years of the crisis were marked by a great deal of confusion over what caused the disease, who it affected and how it spread.

But the naming itself – acquired immunodeficiency syndrome, which we now know is caused by the human immunodeficiency...

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