Researchers have created a platform, called SIMPL2, that revolutionizes the study of protein-protein interactions by simplifying detection while improving measurement accuracy. While protein-protein interactions have previously been considered 'undruggable' using small molecules, the platform addresses this challenge by facilitating the measurement of these interactions -- improving our understanding of the types of molecules needed to control them.
Read more …Researchers develop tool to fast-track measurement of protein interactions for drug discovery
Researchers have unveiled a critical mechanism that links cellular stress in the brain to the progression of Alzheimer's disease (AD). The study highlights microglia, the brain's primary immune cells, as central players in both the protective and harmful responses associated with the disease.
Read more …New research identifies key cellular mechanism driving Alzheimer's disease
Hospitals that have adopted the Center for Medicare and Medicaid (CMS) 'hospital-at-home' program, which serves as an alternative to admission to brick-and-mortar facilities, are concentrated in large, urban, not-for-profit, and academic hospitals, highlighting need for targeted incentives to expand program to smaller, rural, and non-teaching hospitals.
Read more …Adoption of 'hospital-at-home' programs remains concentrated among larger, urban, not-for-profit...