The earliest stages of mammalian embryo development are like an orchestra performance, where everyone must play at the exact right moment and in perfect harmony. New research identifies one of the conductors making sense of the chaos.
Read more …How a 'conductor' makes sense of chaos in early mouse embryos
Understanding how mucus changes, and what it changes in response to, can help diagnose illnesses and develop treatments. Researchers develop a system to grow mucus-producing intestinal cells and study the characteristics of the mucus in different conditions. The process involves growing a layer of intestinal cells on a laboratory plate exposed to air. These cells produce a layer of mucus that the researchers can easily access for testing. Using a magnetic wire, they can measure the consistency of the mucus without affecting its properties, and the platform can explore the effects of pathogens and help develop medications to combat them.
Read more …Seeking medical insights in the physics of mucus
Researchers used a breast cancer cell line panel and primary tumor explants from breast and cervical cancer patients to examine two different cellular contractility modes: one that generates collective tissue surface tension that keeps cell clusters compact and another, more directional, contractility that enables cells to pull themselves into the extracellular matrix. They found that more aggressive cells pull more strongly on the ECM than on themselves while noninvasive cells pull more strongly on themselves than on the ECM -- and that the different pulling behaviors are attributed to different structures of actin cytoskeleton inside the cells.
Read more …Study sheds light on cancer cell 'tug-of-war'