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Saturday, April 26, 2025

Every cell has a story: Tumor and immune cell interactions within craniopharyngiomas

Craniopharyngiomas are brain tumors that negatively impact the hormonal function of the nearby pituitary. The tumor location often prevents necessary surgical intervention. Alternative pharmacological therapy requires an in-depth understanding of the tumor molecular characteristics. To address this gap, researchers analyzed gene expression within individual tumor cells. This study reports the molecular features and interactions of tumor and immune cells associated with two craniopharyngioma subtypes that will help identify future targeted therapeutics.

Treating prostate cancer with novel platinum complex via targeting androgen receptor signaling

Prostate cancer, especially in advanced stages such as castration-resistant prostate cancer, is challenging to treat. Traditional therapies targeting androgen receptor (AR) signaling have limited efficacy. In a recent study, researchers investigated the potential of azolato-bridged dinuclear platinum(II) complexes, particularly 5-H-Y, as promising alternatives. Their findings highlight the complex's ability to inhibit AR signaling and induce cell death in prostate cancer cells, providing a new avenue for prostate cancer treatment.

Bioengineered yeast microbes as targeted drug delivery systems

Researchers have developed a groundbreaking way to engineer yeast (Saccharomyces cerevisiae) to create microbial communities that can perform complex tasks and self-regulate their composition in response to external signals.

Practical tips from a clinical psychologist

The holiday season, often considered a time of joy and togetherness, can also be one of the most challenging periods for those who are grieving a loss.

Nearly 95% of people who have experienced loss report dealing with at least one symptom of physical or mental distress ^[1]. Approximately 10% of them develop prolonged grief disorder ^[2], a persistent and debilitating form of grief that does not ease with time.

Often, this grief...

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