The standard medication levodopa does not always work against tremors in Parkinson's disease, especially in stressful situations. Propranolol, however, does work during stress, providing insight into the role of the stress system in tremors. MRI scans reveal that propranolol directly inhibits activity in the brain circuit that controls tremors. Doctors may consider this medication when levodopa is ineffective.
Read more …Propranolol reduces tremors in Parkinson's disease
Researchers have created a platform, called SIMPL2, that revolutionizes the study of protein-protein interactions by simplifying detection while improving measurement accuracy. While protein-protein interactions have previously been considered 'undruggable' using small molecules, the platform addresses this challenge by facilitating the measurement of these interactions -- improving our understanding of the types of molecules needed to control them.
Read more …Researchers develop tool to fast-track measurement of protein interactions for drug discovery