Obesity and inflammatory diseases are increasing in prevalence and contribute to the growing burden of lifestyle disorders such as diabetes and hypertension. There is a lack of naturally derived alternatives to tackle these issues. Researchers have synthesized novel amino acid derivatives of menthol and studied its properties. The menthyl esters showed exceptional anti-inflammatory and anti-obesity activities during preclinical studies and can be developed as therapeutic compounds with further research.
Read more …Fighting fat and inflammation: Scientists develop powerful new compounds
Although drug eruptions are often linked to the human leukocyte antigen (HLA), the mechanism of its involvement in presenting symptoms of the skin remains unclear. In a recent study, researchers used genetically engineered mice to demonstrate the role of HLA in mediating intracellular reactions in keratinocytes, leading to drug eruptions in the skin. Their findings could lead to improved preventive and treatment measures for drug eruptions.
Read more …Exploring the mechanism behind drug eruptions in the skin
Sprint interval training (SIT) is a form of exercise characterized by cycles of intense exercise which are interspersed by short durations of rest. In a recent study, researchers deep dive into the intricate connections among various parameters of SIT, such as duration and repetitions, and the resulting physiological responses. Their findings can aid in developing well-informed and tailored sprint training regimens that significantly benefit the modern-day population.
Read more …Longer sprint intervals can improve muscle oxygen utilization compared to shorter intervals