Experts have developed a breakthrough small-molecule drug, a 'protein degrader'. This molecule, called ACBI3, could potentially lead to new therapies independent of KRAS mutation type, improving outcomes for all patients with cancers caused by KRAS mutations.
Read more …Potential breakthrough for hard to treat cancers
A study has uncovered new insights into how the brain processes and integrates pain information. The research goes beyond identifying brain areas that respond to pain, revealing the mechanisms behind the brain's integration of pain-related information. Using functional magnetic resonance imaging (fMRI), they formalized how the brain combines pain expectations with the actual intensity of painful stimuli.
Read more …How the brain integrates pain prediction and stimuli
The protein 'MIPS' changes its internal structure when it becomes active. Its disordered active centre becomes a defined structure with special functions. The protein plays a key role in the production of inositol, which is also known as vitamin B8, and fulfills important tasks in the body. Researchers have succeeded for the first time in observing the protein as it re-structures.
Read more …From chaos to order: Proteins can re-structure themselves to create important substances
CRISPR-Cas is used broadly in research and medicine to edit, insert, delete or regulate genes in organisms. TnpB is an ancestor of this well-known 'gene scissor' but is much smaller and thus easier to transport into cells. Using protein engineering and AI algorithms, researchers have now enhanced TnpB capabilities to make DNA editing more efficient and versatile, paving the way for treating a genetic defect for high cholesterol in the future.
Read more …Compact 'gene scissor' enables effective genome editing