The ability to alter proteins to refine control over binding affinity and specificity can create tailored therapeutics with reduced side effects, highly sensitive diagnostic tools, efficient biocatalysis, targeted drug delivery systems and sustainable bioremediation solutions. However, various approaches to such protein redesign have time-consuming drawbacks. Researchers now offer a simplified method they call ProteinReDiff that uses artificial intelligence to speed the redesign of ligand-binding proteins.
Read more …Simplified redesign of proteins to improve ligand binding
A new study has identified a group of neurons that, when activated, can induce a hypometabolic state, akin to hibernation. The discovery could have far-reaching implications for conditions like obesity, cardiometabolic diseases, and even for space travel. The research team found that these neurons regulate key aspects of the brain-heart-gut axis.
Read more …Scientists identify neurons in mice that, once activated, can change body's metabolic rate, induce...