Health

Sweet but risky: Common sweeteners may be accelerating puberty in kids

Consuming certain sweeteners commonly found in foods and beverages may increase the risk of early puberty in children, particularly among those who are genetically predisposed, according to a study presented at ENDO 2025, the Endocrine Society's annual meeting in San Francisco, Calif.

The researchers found that consuming aspartame, sucralose, glycyrrhizin and added sugars was significantly associated with a higher risk of early puberty, especially in children with certain genetic traits. The more of these sweeteners the teens consumed, the higher their risk of central precocious puberty.

"This study is one of the first to connect modern dietary habits -- specifically sweetener intake -- with both genetic factors and early puberty development in a large, real-world cohort," said Yang-Ching Chen, M.D., Ph.D., of Taipei Municipal Wan Fang Hospital and Taipei Medical University in Taipei, Taiwan. "It also highlights gender differences in how sweeteners affect boys and girls, adding an important layer to our understanding of individualized health risks."

A type of early puberty known as central precocious puberty is increasingly common. It can lead to emotional distress, shorter adult height, and increased risk of future metabolic and reproductive disorders.

Chen's previous research found that certain sweeteners can directly influence hormones and gut bacteria linked to early puberty. For example, one artificial sweetener called acesulfame potassium or AceK was shown to trigger the release of puberty-related hormones by activating "sweet taste" pathways in brain cells and increasing stress-related molecules. Another sweetener, glycyrrhizin -- found in licorice -- was found to change the balance of gut bacteria and reduce the activity of genes involved in triggering puberty.

"This suggests that what children eat and drink, especially products with sweeteners, may have a surprising and powerful impact on their development," Chen said.

The new findings come from the Taiwan Pubertal Longitudinal Study (TPLS), begun in 2018. The study included data from 1,407 teens. Central precocious puberty was diagnosed in 481 teens. The researchers assessed teens' sweetener intake through validated questionnaires and testing of urine samples. Genetic predisposition was quantified using polygenic risk scores derived from 19 genes related to central precocious puberty. Early puberty was diagnosed based on medical exams, hormone levels and scans.

Sucralose consumption was linked to a higher risk of central precocious puberty in boys and consumption of glycyrrhizin, sucralose and added sugars was associated with a higher risk of central precocious puberty in girls.

"The findings are directly relevant to families, pediatricians and public health authorities," Chen said. "They suggest that screening for genetic risk and moderating sweetener intake could help prevent early puberty and its long-term health consequences. This could lead to new dietary guidelines or risk assessment tools for children, supporting healthier development."

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Deadly disguise: How candy-like nicotine pouches caused a 763% spike in child poisonings

A new study reveals that ingestions of nicotine pouches by young children have surged in recent years. Researchers at the Center for Injury Research and Policy of the Abigail Wexner Research Institute at Nationwide Children's Hospital and the Central Ohio Poison Center analyzed calls to U.S. poison centers and found an alarming 763% increase in the rate of reported nicotine pouch ingestions among children younger than 6 years old from 2020 to 2023. Nicotine pouches were also more likely to be associated with serious medical outcomes or hospital admissions than other nicotine products like gum/lozenges, e-liquids, powder/granules, and tablets/capsules/caplets.

Nicotine pouches, which contain nicotine powder and are placed in the mouth, were not tracked in national poison center data until 2020. However, between 2020 and 2023 (the most recent year of data from the study), the rate of unintentional ingestion of nicotine pouches by young children increased at a fast rate -- even as ingestion rates for other formulations of nicotine declined.

"Nicotine pouches are a serious and growing toxic ingestion hazard among young children," said Hannah Hays, MD, co-author of the study and medical director of the Central Ohio Poison Center.

"The rapid increase in the number and comparative severity of nicotine pouch ingestions is a reminder of the public health challenges of the changing nicotine product market. This is why we need to continue ongoing surveillance and increase our efforts to prevent nicotine ingestions among young children."

The study, published in Pediatrics, also investigated other nicotine products and formulations. Researchers examined nearly 135,000 cases of nicotine ingestions among children younger than 6 years old that were reported to U.S. poison centers from 2010 through 2023. Most ingestions occurred at home and involved children under the age of 2 years. While most exposures resulted in minor or no effects, there were 39 cases with major medical outcomes and two deaths.

The overall rate of all nicotine ingestions increased 59% from 2010-2015 before decreasing 34% from 2015-2023. This rate was primarily driven by the ingestion rate for liquid nicotine and nicotine solid formulations such as tablets, capsules, and caplets. The ingestion rate for liquid nicotine increased by 450% from 2010-2015 and then decreased by 45% from 2015-2023.

"This abrupt change in the rate trend for liquid nicotine ingestions corresponded with the passage of both state and federal legislation, including the Child Nicotine Poisoning Prevention Act of 2015, which required child-resistant packaging of liquid nicotine," said Gary Smith, MD, DrPH, senior author of the study and director of the Center for Injury Research and Policy at Nationwide Children's. "This suggests that legislation can make a difference. However, despite this improvement, the ingestion rate for liquid nicotine remained higher than the rates for any other nicotine product, which clearly indicates that there are opportunities for further improvement.

"Many nicotine products are flavored and sold in colorful packaging that may be attractive to a young child," said Dr. Smith. "Banning flavors in all nicotine products helps reduce unintentional ingestions by young children as well as discourage use among teens."

Researchers also shared a few safety tips for parents and caregivers of young children. The safest choice is to keep all nicotine products out of the home. If you choose to have them in your home, you can lower the risk by following these steps:

Store nicotine products safely. If these products are kept in the home, store them up, away from food, and out of sight -- preferably in a locked cabinet, drawer or box. While storing these products in purses or backpacks is not recommended when you have young children that live in or visit your home, if you are going to keep them in these places, make sure to store the purse/backpack up, away, and out of sight of children. Ask that caregivers around your child do the same in their homes.
Avoid using these products in front of children. It is helpful to not use these products in front of your children, especially if packaged to look like treats.
Save the national Poison Help Line number (1-800-222-1222) in your phone and post it in a visible place in your home. The Poison Help Line provides free, confidential advice from experts, 24 hours per day, seven days per week.

Data for this study were obtained from the National Poison Data System (NPDS), which is maintained by America's Poison Centers. Poison centers receive phone calls through the national Poison Help Line (1-800-222-1222) and document information about the exposure, which is reported to the NPDS.

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