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Friday, April 25, 2025

Scientists discover new target for reversible, non-hormonal male birth control

Scientists discovered a new target for reversible, non-hormonal male birth control. The drug, an HDAC inhibitor, blocked sperm production and fertility in male mice without affecting libido or future reproduction.

Oocytes outsmart toxic proteins to preserve long-term female fertility

The accumulation of misfolded or damaged proteins in long-lived, non-dividing cells like neurons are linked to neurodegenerative diseases like Alzheimer's. A study now finds that the build-up of these toxic proteins also influences oocyte quality and female fertility. The researchers discovered that mouse oocytes have specialized structures which roam the cytoplasm and act like a clean-up crew which capture and hold onto protein aggregates, rendering them harmless. Failure to degrade the toxic proteins led to the formation of defective eggs. 3 in 5 (60%) of mouse embryos that inherited the toxic proteins failed to complete the very earlies stages of development. The study presents a new frontier to explore the underlying mechanisms of poor oocyte quality, which is the leading cause of female infertility.

A pharmacologist explains the controversy

The herbal substance kratom ^[1], derived from the leaves of a Southeast Asian tree ^[2], is used by nearly 2 million people ^[3] in the United States annually. It can be easily purchased at gas stations and convenience stores, smoke shops and online, and is

Footballer Tom Lockyer shows life-saving defibrillator in his chest

The Luton Town defender collapsed on the pitch after a cardiac arrest last December.

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