Glioblastoma is the most common and most aggressive primary brain tumor, with an average survival after diagnosis of less than two years, and against which current treatments remain ineffective. In recent years, immunotherapies have given patients renewed hope, albeit with relatively modest success. A team has succeeded in identifying a specific marker on the surface of tumour cells, and in generating immune cells carrying an antibody to destroy them. Furthermore, these cells, called CAR-T cells, appear to be capable of targeting diseased cells in the tumor that do not carry this antigen, while sparing healthy cells.
Read more …Programming cells to target brain tumors

A new study reveals that extreme heat significantly affects daily activities, leading people to reduce outdoor time and alter transportation choices. Vulnerable groups, such as low-income individuals without cars, face greater risks, as they are less able to avoid dangerous conditions. The study calls for targeted policy interventions, including shaded public spaces, heat day declarations and urban design improvements, to mitigate the impact of rising temperatures, particularly on the most vulnerable populations.
Read more …Extreme heat impacts daily routines and travel patterns

The use of circadian-informed lighting, where artificial lighting is synchronised to the natural biological rhythms or a person's 'body-clock', significantly improves quality of sleep and work performance for night shift workers, a major new trial has found. The trial is amongst the first tightly controlled in-laboratory studies to have simultaneously evaluated circadian-lighting effects on markers of body-clock timing, work-shift cognitive performance, and sleep following an abrupt transition to night shift work.
Read more …Light at the end of the tunnel for night shift workers

When it comes to drug pricing, the Trump and Biden-Harris administrations both have some very modest wins to tout.

As director of the Health Outcomes, Policy, and Evidence Synthesis group[1] at the University of Connecticut School of Pharmacy, I teach and study[2] about the ethics of prescription drug prices and the complexities of drug pricing[3] nationally.

Delving into the presidential candidates’ successes on a number of...

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