Tumor cells circulating in the blood are the 'germ cells' of breast cancer metastases. They are very rare and could not be propagated in the culture dish until now, which made research into therapy resistance difficult. A team has now succeeded for the first time in cultivating stable tumor organoids directly from blood samples of breast cancer patients. Using these mini-tumors, the researchers were able to decipher a molecular signaling pathway that ensures the cancer cells' survival and resistance to therapy. With this knowledge, the team was able to develop an approach to specifically eliminate these tumor cells in lab experiments.
Read more …Approaches against metastatic breast cancer: mini-tumors from circulating cancer cells
A genetic fault long believed to drive the development of esophageal cancer may in fact play a protective role early in the disease. This unexpected discovery could help doctors identify which individuals are at greater risk of developing cancer, potentially leading to more personalized and effective preventive strategies.
Read more …Surprising 'two-faced' cancer gene role supports paradigm shift in predicting disease