Researchers identify mutations that can lead to resistance to some chemotherapies

Investigators have uncovered how resistance to chemotherapies may occur in some cancers. Researchers focused on a pathway that harnesses reactive oxygen species (ROS) to kill cancer cells. The study found that mutations to VPS35, a key player in this pathway, can prevent chemotherapy-induced cell death. These results could help pinpoint treatment-resistant tumors.

Investigators have uncovered how resistance to chemotherapies may occur in some cancers. Researchers focused on a pathway that harnesses reactive oxygen species (ROS) to kill cancer cells. The study found that mutations to VPS35, a key player in this pathway, can prevent chemotherapy-induced cell death. These results could help pinpoint treatment-resistant tumors.

Read more https://www.sciencedaily.com/releases/2025/03/250328201046.htm