Aging-related genomic culprit found in Alzheimer's disease

Researchers have developed a way to study aged neurons in the lab without a brain biopsy, allowing them to accurately model the effects of aging in the development of late-onset Alzheimer's disease. By studying these cells, the researchers identified aspects of cells' genomes -- called retrotransposable elements, which change their activity as we age -- in the development of late-onset Alzheimer's disease. The findings suggest new treatment strategies targeting these factors.

Researchers have developed a way to study aged neurons in the lab without a brain biopsy, allowing them to accurately model the effects of aging in the development of late-onset Alzheimer's disease. By studying these cells, the researchers identified aspects of cells' genomes -- called retrotransposable elements, which change their activity as we age -- in the development of late-onset Alzheimer's disease. The findings suggest new treatment strategies targeting these factors.

Read more https://www.sciencedaily.com/releases/2024/08/240801142246.htm