Grow the skin you're in: In vivo generation of chimeric skin grafts

Researchers found that mutated mouse embryos showing an abnormal epidermal differentiation and injected with mouse pluripotent stem cells grew large patches of mature epidermis derived from the donor cells that survived transplantation to adult mice and grew natural-looking fur. Injecting the embryos with human keratinoctyes produced sheets of semi-humanized skin, suggesting that this system could be developed further to grow autologous skin grafts for treating severe skin wounds.

Researchers found that mutated mouse embryos showing an abnormal epidermal differentiation and injected with mouse pluripotent stem cells grew large patches of mature epidermis derived from the donor cells that survived transplantation to adult mice and grew natural-looking fur. Injecting the embryos with human keratinoctyes produced sheets of semi-humanized skin, suggesting that this system could be developed further to grow autologous skin grafts for treating severe skin wounds.

Read more https://www.sciencedaily.com/releases/2024/05/240529144248.htm