Metformin during pregnancy affects the brain development in offspring mice, study finds

With the rise in gestational diabetes and metabolic disorders during pregnancy, metformin is also being prescribed more frequently. Although it is known that the oral antidiabetic agent can cross the placental barrier, the impacts on the brain development of the child are largely unknown. Researchers have now been able to demonstrate in a mouse model that although metformin has positive effects in pregnant animals, it does not in the offspring.

With the rise in gestational diabetes and metabolic disorders during pregnancy, metformin is also being prescribed more frequently. Although it is known that the oral antidiabetic agent can cross the placental barrier, the impacts on the brain development of the child are largely unknown. Researchers have now been able to demonstrate in a mouse model that although metformin has positive effects in pregnant animals, it does not in the offspring.

Read more https://www.sciencedaily.com/releases/2024/03/240320160537.htm